Antinociceptive effect of Elaeagnus angustifolia fruit seeds in mice

被引：52
|
作者：
Ramezani, M [1 ]
Hosseinzadeh, H [1 ]
Daneshmand, N [1 ]
机构：
[1] Mashhad Univ Med Sci, Fac Pharm, Mashhad, Iran
来源：
FITOTERAPIA | 2001年 / 72卷 / 03期
关键词：
Elaeagnus angustifolia; antinociceptive activity;
D O I：
10.1016/S0367-326X(00)00290-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The antinociceptive effect of different Elaeagnus angustifolia fruit seed extractives was studied in mice using hot-plate and writhing tests. Following intraperitoneal injection, the decoction (EaDE), the ethanol extract (EaEE), the aqueous and n-butanol fractions (EaAF, and EaBF, respectively) of a polyphenolic fraction, and two flavonoid-enriched fractions of EaBF (EaBCF1 and EaBCF2) showed significant antinociceptive activity in both tests, markedly and dose-dependently increasing the pain threshold. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：255 / 262
页数：8
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