Synthesis of furoxan derivatives of diclofenac as potent anti-inflammatory agents with reduced GI toxicity

被引:0
|
作者
Amir, Mohd [1 ]
Akhter, Md Wasim [1 ]
Somakala, K. [1 ]
机构
[1] Hamdard Univ, Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India
来源
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2016年 / 55卷 / 08期
关键词
Diclofenac; nitric oxide donors; furoxan; anti-inflammatory; ulcerogenicity; lipid peroxidation; hepatotoxic effect; histopathological studies; NO-DONORS; DRUGS; ASSAY; SERUM; ACID;
D O I
暂无
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new series of NO donating furoxan derivatives of diclofenac have been synthesized by linking diclofenac to selected furoxan moieties and have been investigated for their anti-inflammatory, analgesic, ulcerogenic, lipid peroxidation, hepatotoxicity, histopathological and NO releasing properties. All the hybrid derivatives are endowed with anti-inflammatory activity comparable to diclofenac but unlike this drug they show reduced GI toxicity. The compounds 4-[(2-(2-(2-(2,6-dichlorophenylamino)phenyl)acetamido)ethoxy)carbonyl]-3-methyl furoxan 12 having amide-ester linkage and 4-[(2-(2-(2,6-dichlorophenylamino)phenyl)acetoxy)methyl]1-3-methyl-furoxan 13a having ester linkage show greater anti-inflammatory activity comparable to standard drug diclofenac. These compounds 12 and 13a also show higher gastrointestinal protection in comparison to standard drug diclofenac.
引用
收藏
页码:989 / 998
页数:10
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