Metal-Free Aminooxygenation of Alkynes: Efficient Synthesis of 3-Aroylimidazo[1,2-a]-N-Heterocycles

被引：16
|
作者：
Reddy, K. Ranjith [1 ,2 ]
Gupta, Ajai Prakash [3 ]
Das, Parthasarathi [1 ,2 ]
机构：
[1] Acad Sci & Innovat Res AcSIR, New Delhi 110020, India
[2] Indian Inst Integrat Med, Jammu 180001, India
[3] Indian Inst Integrat Med IIIM, Qual Control & Qual Assurance QC & QA, Jammu 180001, India
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 5卷 / 07期
关键词：
2-aminopyridines; aminooxygenation; 3-aroylimidazo[1; 2-a]pyrazines; 2-b]pyridazines; imidazo[1; 2-a]pyridines; N BOND FORMATION; ONE-POT; C-N; 3-COMPONENT REACTION; GOLD; DERIVATIVES; DISCOVERY; PYRIDINES; 2-AMINOPYRIDINES; INHIBITOR;
D O I：
10.1002/ajoc.201600120
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An expeditious, one-pot, N-iodosuccinimide-promoted reaction has been developed for the synthesis of 3-aroylimidazo[1,2-a]pyridines from 3-phenylpropiolaldehyde and 2-aminopyridines.This aminooxygenation process of alkynes is general and was successfully extended to access 3-aroylimidazo[1,2-a]pyrazines and 3-aroylimidazo[1,2-b]pyridazines. With the metal-free conditions and great efficiency in expanding molecule diversity, this method is superior to the existing procedures in the synthesis of 3-aroylimidazo[1,2-a]-N-heterocycles.
引用
收藏
页码：900 / 906
页数：7
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