Death squads enlisted by the tumour suppressor p53

被引：97
|
作者：
Michalak, E
Villunger, A
Erlacher, M
Strasser, A [1 ]
机构：
[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia
[2] Innsbruck Med Univ, Bioctr, Div Pathophysiol, Innsbruck, Austria
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 331卷 / 03期
基金：
英国医学研究理事会; 美国国家卫生研究院; 奥地利科学基金会;
关键词：
apoptosis; p53; cancer; PUMA; Noxa; BCL-2;
D O I：
10.1016/j.bbrc.2005.03.183
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
p53 is a tumour suppressor that is found mutated or functionally inactivated in more than half of all human cancers. p53 function is activated by DNA damage, hypoxia, expression of certain oncogenes, and many cytotoxic stimuli. p53 is a transcription factor that regulates expression of target genes which promote apoptotic cell death, cell cycle arrest.. cellular senescence, and some other processes. In this review we summarise current knowledge of p53 target genes implicated in apoptosis signalling. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：786 / 798
页数：13
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