Metal complexes of 4-amino-N-(2-pyrimidinyl)benzene sulfonamide: Synthesis, characterization and Antiprotozoal studies

被引：15
|
作者：
Ajibade, Peter A.
Kolawole, Gabriel A.
O'Brien, Paul
机构：
[1] Univ Zululand, Dept Chem, ZA-3886 Kwa Dlangezwa, South Africa
[2] Univ Ft Hare, Dept Chem, Alice, South Africa
[3] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England
来源：
SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY | 2007年 / 37卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
sulfadiazine; metal complexes; antiprotozoal; Plasmodium falciparum; malaria; sleeping sickness;
D O I：
10.1080/15533170701608957
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
We present the synthesis, characterization and in vitro anti-protozoal studies of Cu(II), Zn(II), Mn(II), Ni(II), Pd(II), Pt(II), and VO(II) complexes of sulfadiazine. Elemental analysis, IR, UV-Vis, room temperature magnetic moments were used to characterize the complexes. Cu(II), Zn(II), Mn(II), Ni(II), and VO(II) formed octahedral complexes formulated as [M(SD)(2)(H2O)(2)]. xH(2)O, (SD = sulfadiazine), while Pd(II) and Pt(II) formed square planar complexes containing one molecule of sulfadiazine. In all the complexes, the sulfadiazine acts as a bidentate ligand coordinating through the sulfonamido N-atom and the pyrimidinic N-atom. The complexes were screened against the resistant strains of Plasmodium falciparum, T.b. rhodosiense and L. donovani to determine their antiprotozoal activities.
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页码：653 / 659
页数：7
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