Caveolin-1 contributes to anoikis resistance in human gastric cancer SGC-7901 cells via regulating Src-dependent EGFR-ITGB1 signaling

被引：20

作者：

Wang, Ke ^{[1
]}

Zhu, Xue ^{[1
]}

Mei, Dan ^{[2
]}

Ding, Zhongyang ^{[2
]}

机构：

[1] Jiangsu Inst Nucl Med, Key Lab Nucl Med, Jiangsu Key Lab Mol Nucl Med, Minist Hlth, Wuxi, Peoples R China

[2] Nanjing Univ Chinese Med, Dept Gen Surg, Wuxi TCM Hosp, Wuxi 214071, Jiangsu, Peoples R China

来源：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2018年 / 32卷 / 10期

关键词：

anoikis resistance; caveolin-1; epidermal growth factor receptor-integrin signaling; gastric cancer; PROGRESSION; METASTASIS; ACTIVATION; EGFR; EXPRESSION; MIGRATION; PATHWAY;

D O I：

10.1002/jbt.22202

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anoikis resistance is considered to be an essential prerequisite of tumor metastasis and which is an important mechanism in the metastatic process of gastric cancer (GC). Caveolin-1 (CAV-1), a protein component of caveolae, has been reported to regulate several cancer cell behaviors including anoikis resistance. However, the role of CAV-1 in the acquisition of anoikis resistance in GC cells has never been explored. In this study, we investigated the promoting effect of CAV-1 on anchorage-independent growth and anoikis resistance, and the involvement of the related signaling pathways in such process in SGC-7901 cells. The results showed that CAV-1 could promote anchorage-independent growth and anoikis resistance in detached SGC-7901 cells, which was associated with the activation of Src-dependent epidermal growth factor receptor-integrin signaling as well as the phosphorylation of PI3K/Akt and MEK/ERK signaling pathways. The data from this study might contribute to the in-depth understanding of the metastatic mechanism for GC.

引用

页数：7