Hematopoietic stem and progenitor cell trafficking

被引：121
|
作者：
Mazo, Irina B. [3 ,4 ]
Massberg, Steffen [1 ,2 ]
von Andrian, Ulrich H. [3 ,4 ]
机构：
[1] Tech Univ Munich, Klinikum Rechts Isar, Deutsch Herzzentrum Munchen, D-8000 Munich, Germany
[2] Tech Univ Munich, Klinikum Rechts Isar, Med Klin 1, D-8000 Munich, Germany
[3] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[4] Immune Dis Inst, Boston, MA 02115 USA
来源：
TRENDS IN IMMUNOLOGY | 2011年 / 32卷 / 10期
关键词：
UMBILICAL-CORD BLOOD; PRE-B-CELL; BONE-MARROW; STEM/PROGENITOR CELLS; CD34(+) CELLS; CHEMOKINE RECEPTORS; ADHESION MOLECULES; AORTIC ENDOTHELIUM; SELECTIN LIGANDS; STROMAL CELLS;
D O I：
10.1016/j.it.2011.06.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Migration of hematopoietic stem cells (HSCs) is essential during embryonic development and throughout adult life. During embryogenesis, trafficking of HSCs is responsible for the sequential colonization of different hematopoietic organs by blood-producing cells. In adulthood, circulation of HSCs maintains homeostasis of the hematopoietic system and participates in innate immune responses. HSC trafficking is also crucial in clinical settings such as bone marrow (BM) and stem cell transplantation. This review provides an overview of the molecular and cellular signals that control and fine-tune trafficking of HSCs and hematopoietic progenitor cells in embryogenesis and during postnatal life. We also discuss the potential clinical utility of therapeutic approaches to modulate HSC trafficking in patients.
引用
收藏
页码：493 / 503
页数：11
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