THE CHEMISORPTION-RELEASE AND ANTIBACTERIAL POTENTIAL STUDIES OF GENTAMICIN FROM HYDROXYAPATITE-BASED IMPLANTS

被引：0

作者：

Varut, Renata-Maria ^{[1
]}

Manda, Valentin ^{[1
]}

Gingu, Oana ^{[2
]}

Sima, Gabriela ^{[2
]}

Teisanu, Cristina ^{[2
]}

Neamtu, Johny ^{[1
]}

机构：

[1] Univ Med & Pharm Craiova, Fac Pharm, Craiova 200349, Romania

[2] Univ Craiova, Fac Mech, Craiova 200512, Romania

来源：

JOURNAL OF SCIENCE AND ARTS | 2020年 / 02期

关键词：

chemisorption; release; gentamicin; antibacterial effect; GC-MS; HPLC; TLC;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The treatment of bone and joint infections is very difficult to achieve, the challenge being to create antibiotic-functionalized implants on their surface, for local release at the bone level of the pharmacologically active agent. In the present study we performed implants based on hydroxyapatite (HAp), HAp reinforced with titanium particles (HApTi) and HapTi with added calcium fructoborate (CaFb) by chemisorption deposition method (HApTiCaFb). The implants was immersed in gentamicin (GTN) solution for 48 hours, then was determined the release profile of antibiotic for 14 days and the antibacterial effect of the three types of composite. The period of antibiotic release may be considered as sufficient to support osteointegration under antibacterial protection.

引用

页码：459 / 466

页数：8

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