THE CHEMISORPTION-RELEASE AND ANTIBACTERIAL POTENTIAL STUDIES OF GENTAMICIN FROM HYDROXYAPATITE-BASED IMPLANTS

The treatment of bone and joint infections is very difficult to achieve, the challenge being to create antibiotic-functionalized implants on their surface, for local release at the bone level of the pharmacologically active agent. In the present study we performed implants based on hydroxyapatite (HAp), HAp reinforced with titanium particles (HApTi) and HapTi with added calcium fructoborate (CaFb) by chemisorption deposition method (HApTiCaFb). The implants was immersed in gentamicin (GTN) solution for 48 hours, then was determined the release profile of antibiotic for 14 days and the antibacterial effect of the three types of composite. The period of antibiotic release may be considered as sufficient to support osteointegration under antibacterial protection.