Modification of hydroxyapatite by doping lithium through acid-base reaction

被引：0

作者：

Meng, Sikun ^{[1
,2
]}

Yokoi, Taishi ^{[3
]}

Kang, Jingyang ^{[1
,2
]}

Tamura, Yukihiko ^{[4
]}

Kawashita, Masakazu ^{[3
]}

Marukawa, Eriko ^{[2
]}

Kasugai, Shohei ^{[1
]}

Kuroda, Shinji ^{[1
,2
,5
]}

Nakata, Hidemi ^{[1
,2
]}

机构：

[1] TMDU, Dept Oral Implantol & Regenerat Dent Med, 1-5-45 Yushima,Bunkyo Ku, Tokyo 1138510, Japan

[2] TMDU, Dept Regenerat & Reconstruct Dent Med, 1-5-45 Yushima,Bunkyo Ku, Tokyo 1138510, Japan

[3] TMDU, Inst Biomat & Bioengn, 2-3-10 Kanda Surugadai,Chiyoda Ku, Tokyo 1010062, Japan

[4] TMDU, Grad Sch Med & Dent Sci, Dept Biomatrix, Pharmacol, 1-5-45 Yushima,Bunkyo Ku, Tokyo 1138510, Japan

[5] Hokkaido Univ Hosp, Ctr Adv Oral Med, Clin Oral Implants, Kita 14,Nishi 5,Kita Ku, Sapporo, Hokkaido 0608648, Japan

来源：

JOURNAL OF THE CERAMIC SOCIETY OF JAPAN | 2022年 / 130卷 / 09期

关键词：

Lithium doping; Nano-sized hydroxyapatite; Co-precipitation; Acid-base route; Salt route; SUBSTITUTED HYDROXYAPATITES; IN-VITRO; OSTEOCONDUCTIVITY;

D O I：

10.2109/jcersj2.22077

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Lithium (Li) doping is increasingly regarded as an effective modification for hydroxyapatite (HA) due to its excellent performances in osteogenesis. However, traditional method involving calcium, lithium and phosphorus salt (salt route) usually brought some unexpected ions, which could influence the properties of the obtained materials largely. In the present study, acid-base reaction (acid-base route) was applied in a chemical coprecipitation method to achieve Li-doped HA in nano size (nLiHA) at various calcium to lithium ratios. Comparisons on structure and chemical composition between the nLiHA materials made from both routes (acidbase route and salt route) were subsequently conducted. As a result, synthesizing nLiHA through acid-base reaction was proved to be a feasible improvement on product purity and crystallinity. ??2022 The Ceramic Society of Japan. All rights reserved.

引用

页码：802 / 806

页数：5

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