Sulfur-mediated difunctionalization of internal and terminal alkynes for the synthesis of α-acetoxy ketones

被引：8
|
作者：
Zhang, Zhong [1 ,2 ]
Li, Pingfan [1 ]
机构：
[1] Beijing Univ Chem Technol, Coll Chem, Beijing 100029, Peoples R China
[2] Shandong Univ, State Key Lab Microbial Technol, Qingdao 266237, Shandong, Peoples R China
来源：
TETRAHEDRON LETTERS | 2020年 / 61卷 / 14期
基金：
中国国家自然科学基金;
关键词：
Activated sulfoxides; Difunctionalization of alkynes; Triflic anhydrides; alpha-Acetoxy ketones; INTERRUPTED PUMMERER REACTION; C-H ALKYLATION; SULFOXIDE; ARYLATION; OXIDATION; EFFICIENT; CONVENIENT; ARENES;
D O I：
10.1016/j.tetlet.2020.151707
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The sulfur-mediated difunctionalization of alkynes is reported to give alpha-acetoxy ketones in a one-pot operation under mild conditions with 19-92% yield. By using wet potassium acetate as both the aqueous base and nucleophilic reagent, both terminal alkynes and internal alkynes could be converted into the alpha-acetoxy ketone products. (C) 2020 Elsevier Ltd. All rights reserved.
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页数：3
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