Synthesis of polyfunctionally substituted benzo[5,6]chromeno[4,3,2-de][1,6]naphthyridines and 5H-benzo[5,6]chromeno[3,4-c]pyridines

被引：0
|
作者：
Shaker, Raafat M. [1 ]
机构：
[1] El Minya Univ, Fac Sci, Dept Chem, El Minya, Egypt
来源：
ARKIVOC | 2006年
关键词：
heterocyclic o-aminonitriles; chromenes; 1,6-naphthyridines;
D O I：
10.3998/ark.5550190.0007.e09
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Cyclocondensation of 2-(3-amino-2-cyano-1H-benzo[f]chromen-1-yl)-malononitrile (1) with beta-dicarbonyles 2a-d, benzoylacetonitrile 2e, malononitrile 2f, and 3-aminocrotononitrile ( 9) gave the benzo[ 5,6] chromeno[ 4,3,2- de][ 1,6] naphthyridines (4a-e, 6 and 11). Refluxing 1 with ammonium acetate in ethanol gave pyridine-3,5-dicarbonitrile 12 that converted in the presence of HCl into 5H-benzo[ 5,6] chromeno-[3,4-c] pyridine 14. The structures of the products were proved by elemental analyses, IR, MS, H-1 and C-13 NMR spectroscopy.
引用
收藏
页码：59 / 67
页数：9
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