Do Symptoms of Depression Interact with Substance Use to Affect HIV Continuum of Care Outcomes?

被引：22

作者：

Fojo, Anthony T. ^{[1
]}

Lesko, Catherine R. ^{[2
]}

Calkins, Keri L. ^{[2
]}

Moore, Richard D. ^{[1
]}

McCaul, Mary E. ^{[1
]}

Hutton, Heidi E. ^{[1
,4
]}

Mathews, William C. ^{[3
]}

Crane, Heidi ^{[4
]}

Christopoulos, Katerina ^{[5
]}

Cropsey, Karen ^{[6
]}

Mugavero, Michael J. ^{[6
]}

Mayer, Kenneth ^{[7
]}

Pence, Brian W. ^{[8
]}

Lau, Bryan ^{[2
]}

Chander, Geetanjali ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[3] Univ Calif San Diego, Sch Med, San Diego, CA 92103 USA

[4] Univ Washington, Sch Med, Seattle, WA USA

[5] Univ Calif San Francisco, Sch Med, San Francisco, CA USA

[6] Univ Alabama Birmingham, Sch Med, Birmingham, AL USA

[7] Harvard Univ, Sch Med, Cambridge, MA 02138 USA

[8] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA

来源：

AIDS AND BEHAVIOR | 2019年 / 23卷 / 03期

关键词：

Alcohol; HIV; Depression; Illicit drug use; Viral suppression; ACTIVE ANTIRETROVIRAL THERAPY; HUMAN-IMMUNODEFICIENCY-VIRUS; HAZARDOUS ALCOHOL-USE; SEVERE MENTAL-ILLNESS; ILLICIT DRUG-USE; VIRAL SUPPRESSION; INFECTED PATIENTS; MEDICATION ADHERENCE; DISEASE PROGRESSION; ANTIDEPRESSANT TREATMENT;

D O I：

10.1007/s10461-018-2269-0

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Few studies examine how depression and substance use interact to affect HIV control. In 14,380 persons with HIV (PWH), we used logistic regression and generalized estimating equations to evaluate how symptoms of depression interact with alcohol, cocaine, opioid, and methamphetamine use to affect subsequent retention in care, maintaining an active prescription for ART, and consistent virologic suppression. Among PWH with no or mild depressive symptoms, heavy alcohol use had no association with virologic suppression (OR 1.00 [0.95-1.06]); among those with moderate or severe symptoms, it was associated with reduced viral suppression (OR 0.80 [0.74-0.87]). We found no interactions with heavy alcohol use on retention in care or maintaining ART prescription or with other substances for any outcome. These results highlight the importance of treating moderate or severe depression in PWH, especially with comorbid heavy alcohol use, and support multifaceted interventions targeting alcohol use and depression.

引用

页码：580 / 591

页数：12

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