Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers

被引：91
|
作者：
Michl, P
Downward, J
机构：
[1] Univ Ulm Klinikum, Innere Med Abt 1, D-89081 Ulm, Germany
[2] Canc Res UK, London Res Inst, Signal Transduct Lab, London, England
来源：
ZEITSCHRIFT FUR GASTROENTEROLOGIE | 2005年 / 43卷 / 10期
关键词：
Akt; protein kinase B; PI-3; kinase; gastrointestinal; tumor; signaling; survival; proliferation; apoptosis; metastasis;
D O I：
10.1055/s-2005-858638
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The lipid kinase phosphoinositide 3-OH kinase (PI3K) and its downstream target Akt, also known as protein kinase B (PKB), are crucial effectors in oncogenic signaling induced by various receptor-tyrosine kinases. In recent years, data are accumulating that PI3K/Akt signaling components are frequently altered in a variety of human malignancies. This review summarizes the major effects of PI3K/Akt signaling on proliferation, survival and resistance to apoptosis, angiogenesis and cell motility in gastrointestinal cancers. In addition, activation of PI3K/Akt by various growth factors, the modulation of downstream targets by Akt-induced phosphorylation as well as novel treatment strategies targeting this pathway in gastrointestinal tumors are discussed.
引用
收藏
页码：1133 / 1139
页数：7
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