Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers

被引：91
|
作者：
Michl, P
Downward, J
机构：
[1] Univ Ulm Klinikum, Innere Med Abt 1, D-89081 Ulm, Germany
[2] Canc Res UK, London Res Inst, Signal Transduct Lab, London, England
来源：
ZEITSCHRIFT FUR GASTROENTEROLOGIE | 2005年 / 43卷 / 10期
关键词：
Akt; protein kinase B; PI-3; kinase; gastrointestinal; tumor; signaling; survival; proliferation; apoptosis; metastasis;
D O I：
10.1055/s-2005-858638
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The lipid kinase phosphoinositide 3-OH kinase (PI3K) and its downstream target Akt, also known as protein kinase B (PKB), are crucial effectors in oncogenic signaling induced by various receptor-tyrosine kinases. In recent years, data are accumulating that PI3K/Akt signaling components are frequently altered in a variety of human malignancies. This review summarizes the major effects of PI3K/Akt signaling on proliferation, survival and resistance to apoptosis, angiogenesis and cell motility in gastrointestinal cancers. In addition, activation of PI3K/Akt by various growth factors, the modulation of downstream targets by Akt-induced phosphorylation as well as novel treatment strategies targeting this pathway in gastrointestinal tumors are discussed.
引用
收藏
页码：1133 / 1139
页数：7
相关论文
共 50 条
  • [1] PI3K/Akt signaling in osteosarcoma
    Zhang, Jian
    Yu, Xiao-Hua
    Yan, Yi-Guo
    Wang, Cheng
    Wang, Wen-Jun
    CLINICA CHIMICA ACTA, 2015, 444 : 182 - 192
  • [2] PI3K/Akt signaling pathway in the neuropathology of Krabbe disease
    Sural-Fehr, T.
    Cantuti-Castelvetri, L.
    Zhu, H.
    Pappas, N.
    Lopez-Rosas, A.
    Bongarzone, E. R.
    JOURNAL OF NEUROCHEMISTRY, 2013, 125 : 255 - 255
  • [3] Molecular mechanisms involved in DNA repair in human cancers: An overview of PI3k/Akt signaling and PIKKs crosstalk
    Alemi, Forough
    Raei Sadigh, Aydin
    Malakoti, Faezeh
    Elhaei, Yusuf
    Ghaffari, Seyed Hamed
    Maleki, Masomeh
    Asemi, Zatollah
    Yousefi, Bahman
    Targhazeh, Niloufar
    Majidinia, Maryam
    JOURNAL OF CELLULAR PHYSIOLOGY, 2022, 237 (01) : 313 - 328
  • [4] The PI3K/AKT/MTOR signaling pathway: The role of PI3K and AKT inhibitors in breast cancer
    Huemer F.
    Bartsch R.
    Gnant M.
    Current Breast Cancer Reports, 2014, 6 (2) : 59 - 70
  • [5] Targeting of PI3K/AKT and MEK Signaling
    de Bono, J. S.
    EUROPEAN JOURNAL OF CANCER, 2011, 47 : S84 - S84
  • [6] The PI3K/Akt/mTOR signaling pathway
    Dennis, P. A.
    ANNALS OF ONCOLOGY, 2011, 22 : 19 - 19
  • [7] PI3K/AKT signaling and systemic autoimmunity
    Patel, RK
    Mohan, C
    IMMUNOLOGIC RESEARCH, 2005, 31 (01) : 47 - 55
  • [8] PI3K signaling in cancer: beyond AKT
    Lien, Evan C.
    Dibble, Christian C.
    Toker, Alex
    CURRENT OPINION IN CELL BIOLOGY, 2017, 45 : 62 - 71
  • [9] PI3K/AKT signaling and systemic autoimmunity
    Rahul K. Patel
    Chandra Mohan
    Immunologic Research, 2005, 31 : 47 - 55
  • [10] PI3K/AKT signaling in tumorigenesis and angiogenesis
    Jiang, Bing-Hua
    BIOMEDICINE & PHARMACOTHERAPY, 2008, 62 (07) : 422 - 423
12345