Direct Alkynylation of Thiophenes: Cooperative Activation of TIPS-EBX with Gold and Bronsted Acids

被引：179
|
作者：
Brand, Jonathan P. [1 ]
Waser, Jerome [1 ]
机构：
[1] Ecole Polytech Fed Lausanne, Lab Catalysis & Organ Synth, EPFL SB ISIC LCSO, CH-1015 Lausanne, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 40期
关键词：
alkynes; cooperative catalysis; direct alkynylation; heterocycles; hypervalent iodine; CATALYZED DIRECT ALKYNYLATION; FIELD-EFFECT TRANSISTORS; DIRECT ARYLATION; HYPERVALENT IODINE; TERMINAL ALKYNES; COPPER; TRIFLUOROMETHYLATION; ETHYNYLATION; HETEROCYCLES; ARENES;
D O I：
10.1002/anie.201003179
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
United we stand! Cooperative activation of the hypervalent-iodine reagent TIPS-EBX with a gold catalyst and a Brønsted acid allowed the first direct ethynylation of thiophenes at room temperature (see scheme; TFA = trifluoroacetic acid). The obtained ethynylthiophenes are important building blocks for organic dyes and electronic materials. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：7304 / 7307
页数：4
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