What is the role of non-native intermediates of β-lactoglobulin in protein folding?

被引：42

作者：

Chikenji, G ^{[1
]}

Kikuchi, M ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Sci, Dept Phys, Toyonaka, Osaka 5600043, Japan

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 26期

关键词：

D O I：

10.1073/pnas.97.26.14273

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mechanism of alpha --> beta transition in folding of beta -lactoglobulin is discussed based on free energy landscape analysis of a long lattice model. It is found that helical propensity of beta -lactoglobulin is driven by conformational entropy and is intrinsically coded in its native structure. We propose a view on a role of folding intermediate, which is "on-pathway" but rich in non-native structures. The present results suggest that the native structure topology plays an important role in alpha --> beta transition.

引用

页码：14273 / 14277

页数：5

共 50 条

[31] Strategic Use of Non-Native Diselenide Bridges to Steer Oxidative Protein Folding
Metanis, Norman
Hilvert, Donald
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (23) : 5585 - 5588
[32] Folding Intermediates, Heterogeneous Native Ensembles and Protein Function
Naganathan, Athi N.
Dani, Rahul
Gopi, Soundhararajan
Aranganathan, Akashnathan
Narayan, Abhishek
JOURNAL OF MOLECULAR BIOLOGY, 2021, 433 (24)
[33] Native protein sequences are designed to destabilize folding intermediates
Isogai, Y
BIOCHEMISTRY, 2006, 45 (08) : 2488 - 2492
[34] Role of non-native aromatic and hydrophobic interactions in the folding of hen egg white lysozyme
Rothwarf, DM
Scheraga, HA
BIOCHEMISTRY, 1996, 35 (43) : 13797 - 13807
[35] Formation of Non-Native β-Lactoglobulin during Heat-Induced Denaturation
Kehoe, Joseph James
Wang, Lizhe
Morris, Edwin R.
Brodkorb, Andre
FOOD BIOPHYSICS, 2011, 6 (04) : 487 - 496
[36] Formation of Non-Native β-Lactoglobulin during Heat-Induced Denaturation
Joseph James Kehoe
Lizhe Wang
Edwin R. Morris
André Brodkorb
Food Biophysics, 2011, 6 : 487 - 496
[37] Interplay between native topology and non-native interactions in the folding of tethered proteins
Krobath, Heinrich
Faisca, Patricia F. N.
PHYSICAL BIOLOGY, 2013, 10 (01)
[38] Non-native protein aggregation kinetics
Roberts, Christopher J.
BIOTECHNOLOGY AND BIOENGINEERING, 2007, 98 (05) : 927 - 938
[39] Transient non-native interactions in early folding intermediates do not influence the folding kinetics of Escherichia coli tryptophan synthase beta(2) subunits
Planchenault, T
Navon, A
Schulze, AJ
Goldberg, ME
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 240 (03): : 615 - 621
[40] Compartmentation of protein folding in vivo:: sequestration of non-native polypeptide by the chaperonin-GimC system
Siegers, K
Waldmann, T
Leroux, MR
Grein, K
Shevchenko, A
Schiebel, E
Hartl, FU
EMBO JOURNAL, 1999, 18 (01): : 75 - 84

← 1 2 3 4 5 →