Combined Hyperspectral and Spectral Domain Optical Coherence Tomography Microscope for Non-invasive Hemodynamic Imaging

被引：1
|
作者：
Skala, Melissa C. [1 ]
Hendargo, Hansford [1 ]
Fontanella, Andrew [2 ]
Dewhirst, Mark W. [2 ]
Izatt, Joseph A. [1 ]
机构：
[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA
[2] Duke Univ, Dept Radiat Oncol, Durham, NC 27710 USA
来源：
OPTICAL TOMOGRAPHY AND SPECTROSCOPY OF TISSUE VIII | 2009年 / 7174卷
关键词：
MICROVASCULATURE; TUMORS; FLOW;
D O I：
10.1117/12.808183
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We have combined hyperspectral imaging with spectral domain optical coherence tomography (SDOCT) to non-invasively image changes in hemoglobin saturation, blood flow, microvessel morphology and sheer rate on the vessel wall with tumor growth. Changes in these hemodynamic variables were measured over 24 hours in dorsal skin fold window chamber tumors. There was a strong correlation between volumetric flow and hemoglobin saturation (rho = 0.89, p = 9 x 10(-6), N = 15), and a moderate correlation between shear rate on the vessel wall and hemoglobin saturation (rho = 0.56, p = 0.03, N=15).
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页数：7
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