Catalytic Chemo-, Regio-, and Enantioselective Bromochlorination of Allylic Alcohols

被引：89

作者：

Hu, Dennis X. ^{[1
]}

Seidl, Frederick J. ^{[1
]}

Bucher, Cyril ^{[1
]}

Burns, Noah Z. ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 11期

关键词：

BROMINE CHLORIDE; RECENT PROGRESS; MONOTERPENES; DICHLORINATION; HALOGENATION;

D O I：

10.1021/jacs.5b01384

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein we describe a highly chemo-, regio-, and enantioselective bromochlorination reaction of allylic alcohols, employing readily available halogen sources and a simple Schiff base as the chiral catalyst. The application of this interhalogeriation reaction to a variety of substrates, the rapid enantioselective synthesis of a bromochlorinated natural product, and preliminary extension of this chemistry to dibromination and dichlorination are reported.

引用

页码：3795 / 3798

页数：4

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