Cyclic phosphate prodrugs of 2′-deoxy-2¢-fluoro-2¢-C-methyl nucleoside analogs as inhibitors of HCV NS5B polymerase

被引:0
|
作者
Reddy, P. Ganapati [1 ]
Bao, Donghui [1 ]
Chang, Wonsuk [1 ]
Chun, Byoung-Kwon [1 ]
Du, Jinfa [1 ]
Nagarathnam, Dhanapalan [1 ]
Rachakonda, Suguna [1 ]
Ross, Bruce S. [1 ]
Zhang, Hai-Ren [1 ]
Bansal, Shalini [1 ]
Espiritu, Christine L. [1 ]
Keilman, Meg [1 ]
Lam, Angela M. [1 ]
Niu, Congrong [1 ]
Steuer, Holly M. [1 ]
Furman, Phillip A. [1 ]
Otto, Michael J. [1 ]
Sofia, Michael J. [1 ]
机构
[1] Pharmasset Inc, Princeton, NJ USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
123-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [31] 2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase
    Kucukguzel, Ilkay
    Satilmis, Gokhan
    Gurukumar, K. R.
    Basu, Amartya
    Tatar, Esra
    Nichols, Daniel B.
    Talele, Tanaji T.
    Kaushik-Basu, Neerja
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 69 : 931 - 941
  • [32] Synthesis and SAR studies on rhodanine analogs as allosteric inhibitors of HCV NS5B polymerase
    Patel, Bhargav
    Kaushik-Basu, Neerja
    Khadtare, Nikhil
    Kr, Gurukumar
    Basu, Amartya
    Arora, Payal
    Talele, Tanaji T.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
  • [33] Novel 4-azido-2-deoxy-nucleoside analogs are potent inhibitors of NS5B-dependent HCV replication
    Smith, D. B.
    Ma, H.
    Le Pogam, S.
    Leveque, V.
    Brown, C.
    Johansson, N. G.
    Kalayanov, G.
    Eriksson, S.
    Usova, E.
    Sund, C.
    Winqvist, A.
    Maltseva, T.
    Smith, M.
    Jiang, W. R.
    Cammack, N.
    Martin, J. A.
    Najera, I.
    Klumpp, K.
    JOURNAL OF HEPATOLOGY, 2007, 46 : S190 - S190
  • [34] Synthesis and anti-HCV activity of β-D-2′-deoxy-2′-α-chloro-2′-β-fluoro and β-D-2′-deoxy-2′-α-bromo-2′-β-fluoro nucleosides and their phosphoramidate prodrugs
    Ovadia, Reuben
    Khalil, Ahmed
    Li, Hao
    De Schutter, Coralie
    Mengshetti, Seema
    Zhou, Shaoman
    Bassit, Leda
    Coats, Steven J.
    Amblard, Franck
    Schinazi, Raymond F.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 27 (04) : 664 - 676
  • [35] Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review
    Xie, Yuanchao
    Ogah, Comfort Alicha
    Jiang, Xiangrui
    Li, Jianfeng
    Shen, Jingshan
    CURRENT DRUG TARGETS, 2016, 17 (13) : 1560 - 1576
  • [36] Synthesis of 4′-Substituted-2′-Deoxy-2′-α-Fluoro Nucleoside Analogs as Potential Antiviral Agents
    Kasthuri, Mahesh
    Li, Chengwei
    Verma, Kiran
    Russell, Olivia Ollinger
    Dickson, Lyndsey
    McCormick, Louise
    Bassit, Leda
    Amblard, Franck
    Schinazi, Raymond F.
    MOLECULES, 2020, 25 (06):
  • [37] Synthesis of 2′-O,4′-C-alkylene-bridged ribonucleosides and their evaluation as inhibitors of HCV NS5B polymerase
    Chapron, Christopher
    Glen, Rebecca
    La Colla, Massimiliano
    Mayes, Benjamin A.
    McCarville, Joseph F.
    Moore, Stephen
    Moussa, Adel
    Sarkar, Ruhul
    Seifer, Maria
    Serra, Ilaria
    Stewart, Alistair
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (12) : 2699 - 2702
  • [38] Discovery of 4′-azido-2′-deoxy-2′-C-methyl cytidine and prodrugs thereof: A potent inhibitor of Hepatitis C virus replication
    Nilsson, Magnus
    Kalayanov, Genadiy
    Winqvist, Anna
    Pinho, Pedro
    Sund, Christian
    Zhou, Xiao-Xiong
    Wahling, Horst
    Belfrage, Anna-Karin
    Pelcman, Michael
    Agback, Tatiana
    Benckestock, Kurt
    Wikstrom, Kristina
    Boothee, Mirva
    Lindqvist, Anneli
    Rydegard, Christina
    Jonckers, Tim H. M.
    Vandyck, Koen
    Raboisson, Pierre
    Lin, Tse-I
    Lachau-Durand, Sophie
    de Kock, Herman
    Smith, David B.
    Martin, Joseph A.
    Klumpp, Klaus
    Simmen, Kenneth
    Vrang, Lotta
    Terelius, Ylva
    Samuelsson, Bertil
    Rosenquist, Asa
    Johansson, Nils Gunnar
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (09) : 3265 - 3268
  • [39] D-2′-Deoxy-2′-fluoro-2′-C-methyl-ribofuranosyl nucleosides: Effect of base modifications on antihepatitis C virus activity
    Wang, Peiyuan
    Sofia, Michael J.
    Chun, Byoung-Kwon
    Du, Jinfa
    Rachakonda, Suguna
    Steuer, Holly Micolochick
    Murakami, Eisuke
    Bao, Haiying
    Nagarathnam, Dhanapalan
    Otto, Michael J.
    Furman, Phillip A.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
  • [40] II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides
    Anilkumar, Gopinadhan N.
    Selyutin, Oleg
    Rosenblum, Stuart B.
    Zeng, Qingbei
    Jiang, Yueheng
    Chan, Tin-Yau
    Pu, Haiyan
    Wang, Li
    Bennett, Frank
    Chen, Kevin X.
    Lesburg, Charles A.
    Duca, Jose
    Gavalas, Stephen
    Huang, Yuhua
    Pinto, Patrick
    Sannigrahi, Mousumi
    Velazquez, Francisco
    Venkatraman, Srikanth
    Vibulbhan, Bancha
    Agrawal, Sony
    Ferrari, Eric
    Jiang, Chuan-kui
    Huang, H. -C.
    Shih, Neng-Yang
    Njoroge, F. George
    Kozlowski, Joseph A.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (01) : 713 - 717