Enantioselective butylation of aliphatic aldehydes by mixed chiral lithium amide n-BuLi dimers

被引：52
|
作者：
Arvidsson, PI [1 ]
Davidsson, O [1 ]
Hilmersson, G [1 ]
机构：
[1] Univ Gothenburg, Dept Chem, S-41296 Gothenburg, Sweden
来源：
TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 03期
关键词：
D O I：
10.1016/S0957-4166(99)00033-6
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The enantioselective butylation of aliphatic aldehydes with mixtures of n-butyllithium and chiral lithium amides in a diethyl ether-dimethoxymethane solvent mixture is described. Enantiomeric excesses ranging from 91 to 98.5% were observed for several aliphatic alcohols. The asymmetric butylation of the prochiral aldehydes proceeds much faster by the mixed lithium amide/n-BuLi complexes than by tetrameric n-BuLi. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：527 / 534
页数：8
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