Formal C-H/C-I Metathesis: Site-Selective C-H Iodination of 2-Aryl Benzoic Acid Derivatives Using Aryl Iodide

被引：7
|
作者：
Gao, Zezhong [1 ,2 ]
Wang, Hang [2 ]
Zhou, Chunlin [2 ]
Wang, Ning [2 ]
Li, Shangda [2 ]
Li, Gang [2 ,3 ]
机构：
[1] Fuzhou Univ, Coll Chem, Fuzhou 350002, Fujian, Peoples R China
[2] Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Coal Ethylene Glycol & Its Related Techno, Fuzhou 350002, Fujian, Peoples R China
[3] Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Shanghai 200240, Peoples R China
来源：
ORGANIC LETTERS | 2022年 / 24卷 / 22期
关键词：
CATALYZED ORTHO-HALOGENATION; REDUCTIVE ELIMINATION; CARBOXYLIC-ACIDS; FUNCTIONALIZATION; BONDS; HALIDES; CYCLIZATION; CLEAVAGE; EXCHANGE; ARENE;
D O I：
10.1021/acs.orglett.2c01224
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
C-H functionalization via functional group metathesis is extremely rare. A protocol of remote site-selective C-H iodination of 2-aryl benzoic acid derivatives via formal C(sp(2))-H/C(sp(2))-I metathesis using readily available 1-iodo-4-methoxy-2-nitrobenzene as the mild iodinating reagent was reported herein. A range of 2-aryl benzoic acid derivatives including 2-(naphthalen-1-yl)benzoic acids and [1,1'-binaphthalene]-2-carboxylic acids were iodinated under mild conditions to give valuable iodinated products in a site- and chemo-selective fashion.
引用
收藏
页码：3926 / 3931
页数：6
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