COX-2 and the vasculature: Angel or evil?

被引：4
|
作者：
Cuccurullo, Chiara
Mezzetti, Andrea
Cipollone, Francesco [1 ,2 ]
机构：
[1] CeSI, Ctr Reg Prevenz Aterosclerosi, I-66013 Chieti, Italy
[2] CeSI, Ctr Ric Clin, I-66013 Chieti, Italy
来源：
CURRENT HYPERTENSION REPORTS | 2007年 / 9卷 / 01期
关键词：
D O I：
10.1007/s11906-007-0013-7
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Cyclooxygenase-2 (COX-2) may modulate atherosclerotic plaque stability or instability according to the prostaglandin synthase coupled with it. Whereas upregulation of COX-2 and prostaglandin ( PG) E synthase is associated with plaque instability, overexpression of COX-2 and lipocalin-type PGD synthase leads to plaque stability. Thus, the role of COX-2 in atherothrombosis appears to be quite complex. In this article we summarize our recent papers investigating mechanisms regulating the expression and pharmacologic modulation of COX-2 in atherosclerotic plaques.
引用
收藏
页码：73 / 80
页数：8
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