The immunomodulatory role of probiotics in allergy therapy

被引：51

作者：

Hajavi, Jafar ^{[1
]}

Esmaeili, Seyed-Alireza ^{[2
,3
]}

Varasteh, Abdol-Reza ^{[4
]}

Vazini, Hossein ^{[5
]}

Atabati, Hadi ^{[6
]}

Mardani, Fatemeh ^{[2
,3
]}

Momtazi-Borojeni, Amir A. ^{[3
,7
]}

Hashemi, Maryam ^{[8
]}

Sankian, Mojtaba ^{[2
]}

Sahebkar, Amirhossein ^{[9
,10
,11
]}

机构：

[1] Gonabad Univ Med Sci, Fac Allied Med, Dept Basic Sci, Gonabad, Iran

[2] Mashhad Univ Med Sci, BuAli Res Inst, Immunol Res Ctr, Fac Med, Mashhad, Iran

[3] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Iran

[4] Mashhad Univ Med Sci, Allergy Res Ctr, Mashhad, Iran

[5] Islamic Azad Univ, Hamedan Branch, Basic Sci Fac, Nursing Dept, Hamadan, Iran

[6] Sabzevar Univ Med Sci, Leishmaniasis Res Ctr, Sabzevar, Iran

[7] Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, Nanotechnol Res Ctr, Mashhad, Iran

[8] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Nanotechnol Res Ctr, Mashhad, Iran

[9] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran

[10] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran

[11] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 03期

关键词：

allergy; immune system; microbiota; probiotics; LACTIC-ACID BACTERIA; LACTOBACILLUS-RHAMNOSUS GG; BLOOD MONONUCLEAR-CELLS; ESCHERICHIA-COLI NISSLE; IMMUNE-RESPONSES; GUT MICROBIOTA; DOUBLE-BLIND; IN-VITRO; PRIMARY PREVENTION; T-CELLS;

D O I：

10.1002/jcp.27263

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The increased incidence of allergic disorders may be the result of a relative fall in microbial induction in the intestinal immune system during infancy and early childhood. Probiotics have recently been proposed as viable microorganisms for the prevention and treatment of specific allergic diseases. Different mechanisms have been considered for this probiotic property, such as generation of cytokines from activated pro-T-helper type 1 after bacterial contact. However, the effects of its immunomodulatory potential require validation for clinical applications. This review will focus on the currently available data on the benefits of probiotics in allergy disease.

引用

页码：2386 / 2398

页数：13

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