E-Cadherin and Alpha-Catenin Expression in Normal, Hyperplastic and Neoplastic Endometrium

被引：0
|
作者：
Carico, Elisabetta [1 ]
Atlante, Marco [3 ]
Giarnieri, Enrico [1 ]
Raffa, Salvatore [2 ]
Bucci, Barbara [4 ]
Giovagnoli, Maria Rosaria [1 ]
Vecchione, Aldo [5 ]
机构：
[1] Univ Roma La Sapienza, Fac Med, UOD Cytopathol 2, I-00198 Rome, Italy
[2] Univ Roma La Sapienza, Fac Med, UOC Diagnost Cellulare 2, I-00198 Rome, Italy
[3] Fabia Mater, Div Ginecol, I-00171 Rome, Italy
[4] S Pietro Fatebenefratelli Hosp, AFAR Ctr Ric, I-00189 Rome, Italy
[5] Ist Tumori G Pascale, Direz Sci, I-80131 Naples, Italy
来源：
ANTICANCER RESEARCH | 2010年 / 30卷 / 12期
关键词：
alpha-Catenin; E-cadherin; down-regulation; immunohistochemistry; endometrium; TYROSINE KINASE SUBSTRATE; OVARIAN TUMOR-CELLS; BETA-CATENIN; DIFFERENTIAL EXPRESSION; PROTEIN INTERACTIONS; ADHESION MOLECULES; GAMMA-CATENIN; HUMAN CANCER; CARCINOMA; INVASIVENESS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of this study was to determine whether modulation of expression of cell adhesion molecules may occur in neoplastic transformation of endometrial epithelium. Materials and Methods: E-Cadherin and alpha-catenin protein expression were evaluated by immunohistochemistry in 124 biopsies representative of normal, hyperplastic and neoplastic endometrium. Results: In normal endometrium (proliferative, secretive and atrophic endometrium) strong homogeneous, E-cadherin and alpha-catenin reactivity was found; 58.3% and 66.6% of biopsies representative of simple hyperplastic endometrium were homogeneously positive for E-cadherin and alpha-catenin, respectively, whereas no samples representative of atypical hyperplasia showed evidence of homogeneous E-cadherin or alpha-catenin expression. No expression of homogeneous E-cadherin was seen in endometrial adenocarcinomas; alpha-catenin homogeneous immunostaining was observed in 2 G1 and 2 G2 out of 22 adenocarcinoma samples (18.2%). A homogeneous co-expression of both molecules was seen only in normal (70%) and simple hyperplastic (46%) endometrium. Conclusion: These results suggest that E-cadherin and alpha-catenin down-regulation might be associated with neoplastic transformation of endometrial tissues.
引用
收藏
页码：4993 / 4997
页数：5
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