Imidazolium chloride-catalyzed synthesis of benzimidazoles and 2-substituted benzimidazoles from o-phenylenediamines and DMF derivatives

被引：30
|
作者：
Gan, Zongjie [1 ,2 ]
Tian, Qingqiang [1 ,2 ]
Shang, Suqin [1 ,2 ]
Luo, Wen [1 ,2 ]
Dai, Zeshu [1 ,2 ]
Wang, Huajun [1 ,2 ]
Li, Dan [1 ,2 ]
Wang, Xuetong [1 ,2 ]
Yuan, Jianyong [1 ,2 ]
机构：
[1] Chongqing Med Univ, Dept Med Chem, Coll Pharm, Chongqing 400016, Peoples R China
[2] Chongqing Med Univ, Chongqing Res Ctr Pharmaceut Engn, Chongqing 400016, Peoples R China
来源：
TETRAHEDRON | 2018年 / 74卷 / 52期
关键词：
Imidazolium chloride; Benzimidazoles; 2-Substituted benzimidazoles; Synthesis; CONVENIENT SYNTHESIS; BENZOTHIAZOLES; HETEROCYCLES; CYCLIZATION; SOLVENT; AMINES; ACIDS; CO2;
D O I：
10.1016/j.tet.2018.11.014
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile, general, and economical synthesis of diversely functionalized benzimidazoles and 2-substituted benzimidazoles has been realized via the imidazolium chloride-catalyzed cyclization of o-phenylenediamines with DMF derivatives. This protocol shows a broad substrate scope for aliphatic, aromatic, and heteroaromatic amides. A series of benzimidazoles and 2-substituted benzimidazoles have been obtained in moderate to excellent yields. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7450 / 7456
页数：7
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