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Goethe Univ Frankfurt, Childrens Hosp, Dept Allergy Pulmonol & Cyst Fibrosis, Theodor Stern Kai 7, DE-60590 Frankfurt, Germany Goethe Univ Frankfurt, Childrens Hosp, Dept Allergy Pulmonol & Cyst Fibrosis, Theodor Stern Kai 7, DE-60590 Frankfurt, Germany