Prevalence of NUDT15 polymorphism among patients with inflammatory bowel disease and its impact on white cell count and thiopurine metabolites

被引:0
|
作者
Cooper, J. [1 ]
Cheong, A. [2 ]
Paramsothy, S. [1 ]
Pudipeddi, A. [1 ]
Leong, R. W. [1 ]
机构
[1] Concord Hosp, Gastroenterol & Liver Serv, Sydney, NSW, Australia
[2] Royal Prince Alfred Hosp, Dept Med Genom, Sydney, NSW, Australia
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
229
引用
收藏
页码:125 / 126
页数:2
相关论文
共 50 条
  • [31] Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine
    Akiyama, Shintaro
    Matsuoka, Katsuyoshi
    Fukuda, Kyoko
    Hamada, Shunsuke
    Shimizu, Mikiko
    Nanki, Kosaku
    Mizuno, Shinta
    Kiyohara, Hiroki
    Arai, Mari
    Sugimoto, Shinya
    Iwao, Yasushi
    Ogata, Haruhiko
    Hisamatsu, Tadakazu
    Naganuma, Makoto
    Motobayashi, Maiko
    Suzuki, Kohei
    Takenaka, Kento
    Fujii, Toshimitsu
    Saito, Eiko
    Nagahori, Masakazu
    Ohtsuka, Kazuo
    Mochizuki, Mayumi
    Watanabe, Mamoru
    Hashiguchi, Masayuki
    Kanai, Takanori
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2019, 34 (10) : 1751 - 1757
  • [32] Long-term efficacy and tolerability of dose-adjusted thiopurine treatment in maintaining remission in inflammatory bowel disease patients with NUDT15 heterozygosity
    Maeda, Takato
    Sakuraba, Hirotake
    Hiraga, Hiroto
    Yoshida, Shukuko
    Kakuta, Yoichi
    Kikuchi, Hidezumi
    Kawaguchi, Shogo
    Hasui, Keisuke
    Tatsuta, Tetsuya
    Chinda, Daisuke
    Mikami, Tatsuya
    Fukuda, Shinsaku
    INTESTINAL RESEARCH, 2022, 20 (01) : 90 - +
  • [33] Association of NUDT15 Gene Polymorphism with Cellular Metabolism of Thiopurine in BCP-ALL Cell Lines
    Somazu, Shinpei
    Tanaka, Yoichi
    Abe, Masako
    Kagami, Keiko
    Harama, Daisuke
    Murakami, Yasushi
    Watanabe, Atsushi
    Akahane, Koushi
    Goi, Kumiko
    Yang, Jun
    Moriyama, Takaya
    Inukai, Takeshi
    PEDIATRIC BLOOD & CANCER, 2019, 66 : S18 - S18
  • [34] Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease: A Multicenter Analysis
    Chao, Kang
    Wang, Xueding
    Cao, Qian
    Qian, Jiaming
    Wu, Kaichun
    Zhu, Xia
    Yang, Hong
    Liang, Jie
    Lin, Lang
    Huang, Zicheng
    Zhang, Yu
    Huang, Yibiao
    Sun, Yinghao
    Xue, Xianmin
    Huang, Min
    Hu, Pinjin
    Lan, Ping
    Gao, Xiang
    INFLAMMATORY BOWEL DISEASES, 2017, 23 (09) : 1592 - 1599
  • [35] Landscape of TPMT and NUDT15 Pharmacogenetic Variation in a Cohort of Canadian Pediatric Inflammatory Bowel Disease Patients
    Kennedy, April M.
    Griffiths, Anne M.
    Muise, Aleixo M.
    Walters, Thomas D.
    Ricciuto, Amanda
    Huynh, Hien Q.
    Wine, Eytan
    Jacobson, Kevan
    Lawrence, Sally
    Carman, Nicholas
    Mack, David R.
    Debruyn, Jennifer C.
    Otley, Anthony R.
    Deslandres, Colette
    El-Matary, Wael
    Zachos, Mary
    Benchimol, Eric, I
    Critch, Jeffrey
    Schneider, Rilla
    Crowley, Eileen
    Li, Michael
    Warner, Neil
    Mcgovern, Dermot P. B.
    Li, Dalin
    Haritunians, Talin
    Rudin, Sarah
    Cohn, Iris
    INFLAMMATORY BOWEL DISEASES, 2024, 30 (12) : 2418 - 2427
  • [36] Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry
    Schaeffeler, Elke
    Jaeger, Simon U.
    Klumpp, Verena
    Yang, Jun J.
    Igel, Svitlana
    Hinze, Laura
    Stanulla, Martin
    Schwab, Matthias
    GENETICS IN MEDICINE, 2019, 21 (09) : 2145 - 2150
  • [37] ITPA polymorphisms do not predict additional risk beyond TPMT and NUDT15 for thiopurine-induced cytopenia in inflammatory bowel disease
    Jena, A.
    Grover, N.
    Bhatia, P.
    Singh, M.
    Lad, D.
    Prasad, K. K.
    Singh, H.
    Dutta, U.
    Sharma, V.
    REVISTA DE GASTROENTEROLOGIA DE MEXICO, 2024, 89 (01): : 25 - 30
  • [38] NUDT15 POLYMORPHISMS PREDICT THE INFLUENCE OF PROLONGED EXPOSURE TO AZATHIOPRINE ON HEMATOLOGIC INDICES IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE
    Wu, Shasha
    Jiao, Chunhua
    Lu, Meijiao
    Cui, Xiufang
    Ma, Jingjing
    Mao, Xiaqiong
    Zhang, Hongjie
    GASTROENTEROLOGY, 2021, 160 (06) : S73 - S73
  • [39] HIGH PREVALENCE OF POLYMORPHISM AND LOW ACTIVITY OF THIOPURINE METHYLTRANSFERASE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE
    Larussa, T.
    Lentini, M.
    Nazionale, I.
    Suraci, E.
    Gallo, L.
    Mancuso, S.
    Larosa, E.
    Abenavoli, L.
    Imeneo, M.
    Luzza, F.
    DIGESTIVE AND LIVER DISEASE, 2011, 43 : S183 - S184
  • [40] High prevalence of polymorphism and low activity of thiopurine methyltransferase in patients with inflammatory bowel disease
    Larussa, Tiziana
    Suraci, Evelina
    Lentini, Margherita
    Nazionale, Immacolata
    Gallo, Luigia
    Abenavoli, Ludovico
    Imeneo, Maria
    Costanzo, Francesco Saverio
    Cuda, Giovanni
    Luzza, Francesco
    EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2012, 23 (03) : 273 - 277