Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species

被引：44
|
作者：
Uddin, MJ
Kokubo, S
Ueda, K
Suenaga, K
Uemura, D
机构：
[1] Univ Ryukyus, Dept Chem Biol & Marine Sci, Okinawa 9030213, Japan
[2] Nagoya Univ, Grad Sch Sci, Dept Chem, Chikusa Ku, Nagoya, Aichi 4648602, Japan
来源：
JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 09期
关键词：
D O I：
10.1021/np010066n
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Four new monochlorinated diterpene alkaloids, haterumaimides F-I (1-4), and two known ones, dichlorolissoclimide and chlorolissoclimide, were isolated from an ascidian Lissoclinum, sp. Their structures with absolute stereochemistries were elucidated by chemical and spectral analyses. Haterumaimides F-I (1-4) inhibited the first cleavage of fertilized sea urchin eggs and exhibited potent to weak cytotoxicities against P388 cells.
引用
收藏
页码：1169 / 1173
页数：5
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