Carboxylic Acid O-H Insertion Reaction of fl-Ester Diazos Enabling Synthesis of fl-Acyloxy Esters

被引：5

作者：

Li, Ziyi ^{[1
]}

Yao, Xinyu ^{[1
]}

Zhang, Xin ^{[1
]}

Mei, Haibo ^{[1
]}

Han, Jianlin ^{[1
]}

机构：

[1] Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Nanjing 210037, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 22期

基金：

中国国家自然科学基金;

关键词：

39;

D O I：

10.1021/acs.joc.2c02023

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Generation of non-stabilized P-ester diazos and their applications in carboxylic acid O-H insertion reactions have been reported, which afford P-acyloxy esters in excellent yield. Varieties of aryl and alkyl-substituted diazos are well tolerated in this insertion reaction under mild and convenient conditions. Moreover, structural modification of the natural product and molecular drug can also be achieved in this reaction. This protocol not only realizes the reaction involving unstable P- ester diazos but also provides an efficient strategy for the synthesis of P- acyloxy esters.

引用

页码：15483 / 15491

页数：9

共 42 条

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