Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F] fluoro-D-glucose positron emission and computed tomography

被引：129

作者：

Esmail, Hanif ^{[1
,2
,3
]}

Lai, Rachel P. ^{[4
]}

Lesosky, Maia ^{[2
,5
]}

Wilkinson, Katalin A. ^{[2
,4
]}

Graham, Christine M. ^{[4
]}

Coussens, Anna K. ^{[2
]}

Oni, Tolu ^{[2
]}

Warwick, James M. ^{[6
]}

Said-Hartley, Qonita ^{[7
]}

Koegelenberg, Coenraad F. ^{[8
]}

Walzl, Gerhard ^{[8
,9
]}

Flynn, JoAnne L. ^{[10
]}

Young, Douglas B. ^{[1
,4
]}

Barry, Clifton E., III ^{[2
,9
,11
,12
]}

O'Garra, Anne ^{[4
,13
]}

Wilkinson, Robert J. ^{[1
,2
,4
]}

机构：

[1] Imperial Coll London, Dept Med, London, England

[2] Univ Cape Town, Inst Infect Dis & Mol Med, Clin Infect Dis Res Initiat, Cape Town, South Africa

[3] Univ Oxford, Radcliffe Dept Med, Oxford, England

[4] Francis Crick Inst Mill Hill Lab, London, England

[5] Univ Cape Town, Sch Publ Hlth & Family Med, Div Epidemiol & Biostat, Cape Town, South Africa

[6] Univ Stellenbosch, Dept Med Imaging & Clin Oncol, Cape Town, South Africa

[7] Groote Schuur Hosp, Dept Radiol, Cape Town, South Africa

[8] Univ Stellenbosch, Dept Med, Cape Town, South Africa

[9] Univ Stellenbosch, Dept Biomed Sci, Fac Med & Hlth Sci, Cape Town, South Africa

[10] Univ Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, Pittsburgh, PA USA

[11] NIAID, TB Res Sect, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[12] Univ Cape Town, Dept Pathol, Cape Town, South Africa

[13] Imperial Coll London, Natl Heart & Lung Inst, London, England

来源：

NATURE MEDICINE | 2016年 / 22卷 / 10期

基金：

英国医学研究理事会; 英国惠康基金; 新加坡国家研究基金会; 美国国家卫生研究院;

关键词：

PULMONARY TUBERCULOSIS; ACTIVE TUBERCULOSIS; FUTURE-PROSPECTS; INFECTION; PREVALENCE; STRATEGIES; DISEASE; ADULTS; LUNG;

D O I：

10.1038/nm.4161

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were substantially more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers that are predictive of progression.

引用

页码：1090 / 1093

页数：4

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