Pseudopeptide synthesis of a pentaazamacrocycle containing two trans-fused cyclohexane rings.

被引:8
|
作者
Neumann, WL [1 ]
Franklin, GW [1 ]
Sample, KR [1 ]
Aston, KW [1 ]
Weiss, RH [1 ]
Riley, DP [1 ]
Rath, N [1 ]
机构
[1] UNIV MISSOURI, ST LOUIS, MO 63121 USA
关键词
D O I
10.1016/S0040-4039(97)00563-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis of a bis-cyclohexyl-fused pentaazamacrocycle via head-to-tail pseudopeptide cyclization chemistry is described. The bis-cyclohexyl-fused cyclic pseudopeptide 11 displays intramolecular hydrogen bonding which has been characterized by variable temperature NMR spectroscopy and X-Ray Crystallography. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:3143 / 3146
页数:4
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