Copper-Catalyzed Synthesis of Indole-Fused Benzodiazepines

被引：20
|
作者：
Biswas, Subhasish [1 ]
Batra, Sanjay [1 ]
机构：
[1] Cent Drug Res Inst, CSIR, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 14-15期
关键词：
benzodiazepines; cascade reactions; copper; coupling; indoles; indolo[3,2-b][1,5]benzodiazepines; TUBULIN POLYMERIZATION; INHIBITORS; DERIVATIVES;
D O I：
10.1002/adsc.201100388
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The copper-catalyzed synthesis of indole-fused benzodiazepine via a cascade reaction between 3-halo-1H-indole-2-carbaldehydes and substituted 1,2-phenylenediamines is reported. Reactions with N-Boc-protected indole-aldehydes are found to be more efficient to afford indole[3,2-b][1,5]benzodiazepines.
引用
收藏
页码：2861 / 2867
页数：7
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