Drosophila as a genetic model for studying pathogenic human viruses

被引：51

作者：

Hughes, Tamara T. ^{[1
]}

Allen, Amanda L. ^{[1
]}

Bardin, Joseph E. ^{[1
]}

Christian, Megan N. ^{[1
]}

Daimon, Kansei ^{[1
]}

Dozier, Kelsey D. ^{[1
]}

Hansen, Caom L. ^{[1
]}

Holcomb, Lisa M. ^{[1
]}

Ahlander, Joseph ^{[1
]}

机构：

[1] NE State Univ, Dept Nat Sci, Tahlequah, OK 74464 USA

来源：

VIROLOGY | 2012年 / 423卷 / 01期

基金：

美国国家科学基金会;

关键词：

Drosophila; Viruses; GAL4/UAS system; Transgenic expression; Model organism; Human pathogens; ACUTE RESPIRATORY SYNDROME; DEPENDENT IMMUNE-RESPONSES; CORONAVIRUS 3A PROTEIN; RNA INTERFERENCE; MELANOGASTER CELLS; DOWN-REGULATION; SINDBIS VIRUS; DENGUE VIRUS; IN-VIVO; EXPRESSION;

D O I：

10.1016/j.virol.2011.11.016

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Viruses are infectious particles whose viability is dependent on the cells of living organisms, such as bacteria, plants, and animals. It is of great interest to discover how viruses function inside host cells in order to develop therapies to treat virally infected organisms. The fruit fly Drosophila melanogaster is an excellent model system for studying the molecular mechanisms of replication, amplification, and cellular consequences of human viruses. In this review, we describe the advantages of using Drosophila as a model system to study human viruses, and highlight how Drosophila has been used to provide unique insight into the gene function of several pathogenic viruses. We also propose possible directions for future research in this area. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1 / 5

页数：5

共 50 条

[21] MOLECULAR-BASIS OF LATENCY IN PATHOGENIC HUMAN VIRUSES
GARCIABLANCO, MA
CULLEN, BR
SCIENCE, 1991, 254 (5033) : 815 - 820
[22] FUZZINESS IN THE CORE OF THE HUMAN PATHOGENIC VIRUSES HCV AND HIV
Ivanyi-Nagy, Roland
Darlix, Jean-Luc
FUZZINESS: STRUCTURAL DISORDER IN PROTEIN COMPLEXES, 2012, 725 : 142 - 158
[23] A genetic model for human polyglutamine-repeat disease in Drosophila melanogaster
Bonini, NM
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1999, 354 (1386) : 1057 - 1060
[24] Drosophila as a Genetic Model for Hematopoiesis
Banerjee, Utpal
Girard, Juliet R.
Goins, Lauren M.
Spratford, Carrie M.
GENETICS, 2019, 211 (02) : 367 - 417
[25] A genetic toolkit for studying transposon control in the Drosophila melanogaster ovary
ElMaghraby, Mostafa F.
Tirian, Laszlo
Senti, Kirsten-Andre
Meixner, Katharina
Brennecke, Julius
GENETICS, 2022, 220 (01)
[26] Studying Circadian Rhythm and Sleep Using Genetic Screens in Drosophila
Axelrod, Sofia
Saez, Lino
Young, Michael W.
CIRCADIAN RHYTHMS AND BIOLOGICAL CLOCKS, PT A, 2015, 551 : 3 - 27
[27] Adhesion of human pathogenic enteric viruses and surrogate viruses to inert and vegetal food surfaces
Deboosere, Nathalie
Pinon, Anthony
Caudrelier, Yvette
Delobel, Alexandre
Merle, Ghislaine
Perelle, Sylvie
Temmam, Sarah
Loutreul, Julie
Morin, Thierry
Estienney, Marie
Belliot, Gael
Pothier, Pierre
Gantzer, Christophe
Vialette, Michele
FOOD MICROBIOLOGY, 2012, 32 (01) : 48 - 56
[28] GENETIC RELATEDNESS OF 2 NUCLEOPOLYHEDROSIS VIRUSES PATHOGENIC FOR ORGYIA-PSEUDOTSUGATA
ROHRMANN, GF
MCPARLAND, RH
MARTIGNONI, ME
BEAUDREAU, GS
VIROLOGY, 1978, 84 (01) : 213 - 217
[29] The hazards of studying human genetic variation
Resnik, DB
POLITICS AND THE LIFE SCIENCES, 1999, 18 (02) : 338 - 340
[30] Drosophila mechanoreceptors as a model for studying asymmetric cell division
Furman, Dagmara P.
Bukharina, Tatyana A.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2011, 55 (02): : 133 - 141

← 1 2 3 4 5 →