Adenoid cystic carcinoma of the head and neck - An update

被引：345

作者：

Coca-Pelaz, Andres ^{[1
]}

Rodrigo, Juan P. ^{[1
,2
]}

Bradley, Patrick J. ^{[3
,4
]}

Poorten, Vincent Vander ^{[4
,5
,6
]}

Triantafyllou, Asterios ^{[7
]}

Hunt, Jennifer L. ^{[8
]}

Strojan, Primoz ^{[9
]}

Rinaldo, Alessandra ^{[10
]}

Haigentz, Missak, Jr. ^{[11
]}

Takes, Robert P. ^{[12
]}

Mondin, Vanni ^{[10
]}

Teymoortash, Afshin ^{[13
]}

Thompson, Lester D. R. ^{[14
]}

Ferlito, Alfio ^{[10
]}

机构：

[1] Hosp Univ Cent Asturias, Dept Otolaryngol, Oviedo, Spain

[2] Univ Oviedo, Inst Univ Oncol Principado Asturias, Oviedo, Spain

[3] Univ Nottingham Hosp, Dept Otorhinolaryngol Head & Neck Surg, Nottingham NG7 2UH, England

[4] European Salivary Gland Soc, Geneva, Switzerland

[5] Katholieke Univ Leuven, Univ Hosp Leuven, Otorhinolaryngol Head & Neck Surg, Leuven, Belgium

[6] Katholieke Univ Leuven, Univ Hosp Leuven, Dept Oncol, Leuven, Belgium

[7] Univ Liverpool, Sch Dent, Oral Pathol, Liverpool L69 3BX, Merseyside, England

[8] Univ Arkansas Med Sci, Dept Pathol, Little Rock, AR 72205 USA

[9] Inst Oncol, Dept Radiat Oncol, Ljubljana, Slovenia

[10] Univ Udine, Sch Med, I-33100 Udine, Italy

[11] Albert Einstein Coll Med, Montefiore Med Ctr, Dept Med, Div Oncol, Bronx, NY 10467 USA

[12] Radboud Univ Nijmegen, Med Ctr, Dept Otolaryngol Head & Neck Surg, Nijmegen, Netherlands

[13] Univ Marburg, Dept Otolaryngol Head & Neck Surg, Marburg, Germany

[14] Woodland Hills Med Ctr, Dept Pathol, Woodland Hills, CA USA

来源：

ORAL ONCOLOGY | 2015年 / 51卷 / 07期

关键词：

Adenoid cystic carcinoma; Head and neck cancer; Salivary gland; Pathology; Molecular biology; Prognosis; SALIVARY-GLAND CARCINOMAS; FACTORS INFLUENCING SURVIVAL; ONCOLOGY COOPERATIVE GROUP; LYMPH-NODE METASTASIS; PHASE-II; IMATINIB MESYLATE; PAROTID CARCINOMA; GROWTH-FACTOR; C-KIT; CLINICOPATHOLOGICAL CORRELATION;

D O I：

10.1016/j.oraloncology.2015.04.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This article provides an update on the current understanding of adenoid cystic carcinoma of the head and neck, including a review of its epidemiology, clinical behavior, pathology, molecular biology, diagnostic workup, treatment and prognosis. Adenoid cystic carcinoma is an uncommon salivary gland tumor that may arise in a wide variety of anatomical sites in the head and neck, often with an advanced stage at diagnosis. The clinical course is characterized by very late recurrences; consequently, clinical follow-up should extend at least >15 years. The optimal treatment is generally considered to be surgery with postoperative radiotherapy to optimize local disease control. Much effort has been invested into understanding the tumor's molecular biological processes, aiming to identify patients at high risk of recurrence, in hopes that they could benefit from other, still unproven treatment modalities such as chemotherapy or biological therapy. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：652 / 661

页数：10

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