Palladium-catalyzed diarylative dearomatization of indoles with aryl thioesters

被引：6
|
作者：
Huang, Wei [1 ]
Han, Ming-Liang [4 ,5 ]
Liu, Yu-Wen [2 ,3 ]
Xu, Hui [2 ]
Dai, Hui-Xiong [2 ,3 ]
机构：
[1] Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China
[2] Chinese Acad Sci, Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[4] Shenzhen Univ, Inst Adv Study, Shenzhen 518060, Peoples R China
[5] Shenzhen Univ, Coll Optoelect Engn, Key Lab Optoelect Devices & Syst, Minist Educ & Guangdong Prov, Shenzhen 518060, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2021年 / 32卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Thioester; Decarbonylation; Dearomatization; Indolines skeleton; Diarylation; THIOL ESTERS; BOND FORMATION; EFFICIENT; DECARBONYLATION; REDUCTION; ALKALOIDS; ALDEHYDES; CLEAVAGE;
D O I：
10.1016/j.cclet.2021.02.048
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report herein a palladium-catalyzed diarylative dearomatization of indole by employing thioester and arylboronic acid as the aryl electrophiles. The reaction involved a decarbonylation/migratory insertion/terminal Suzuki coupling procedure. Substrates bearing various functional groups are well tolerated in the reaction, affording the diarylated indoline skeletons in moderate to good yields. (C) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：2765 / 2768
页数：4
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