Embryonic-like regenerative phenomenon: wound-induced hair follicle neogenesis

被引：8

作者：

Gong, Lin ^{[1
]}

Xu, Xue-Gang ^{[1
]}

Li, Yuan-Hong ^{[1
]}

机构：

[1] China Med Univ, Dept Dermatol, Hosp 1, Shenyang 110001, Liaoning, Peoples R China

来源：

REGENERATIVE MEDICINE | 2018年 / 13卷 / 06期

关键词：

fibroblast; hedgehog signal pathway; IL-6; STAT3 signaling pathway; stem cell; Wnt; -catenin pathway; wound-induced hair follicle neogenesis; BETA-CATENIN ACTIVITY; STEM-CELL NICHE; SIGNALING PATHWAY; EXTRACELLULAR-MATRIX; SKIN DEVELOPMENT; SKELETAL-MUSCLE; EXPRESSION; EPIDERMIS; LINEAGES; GROWTH;

D O I：

10.2217/rme-2018-0028

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Wound-induced hair follicle neogenesis (WIHN) is a regenerative phenomenon that occurs widely in the skin of adult mammalians. A fully functional follicle can regenerate in the center of a full-thickness wound with a large enough size. The cellular origin of this process is similar to embryonic process. Many growth and development-related pathways are involved in WIHN. Studying WIHN can deeply explore the mechanism of biological growth, development and regeneration, and can identify new treatments for hair-related disorders. Our review aims to enlighten future study by summarizing the clinical manifestation of WIHN, as well as the cellular and molecular mechanism of WIHN in recent studies.

引用

页码：729 / 739

页数：11

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