Radiovaccination Strategy for Cancer Treatment Integrating Photodynamic Therapy-Generated Vaccines with Radiotherapy

被引:2
|
作者
Korbelik, Mladen [1 ]
机构
[1] BC Canc, Vancouver, BC V5Z 1L3, Canada
关键词
radiovaccination; cancer vaccine; photodynamic therapy; RADIATION-THERAPY; TUMOR-CELLS; IMMUNOGENIC MODULATION; IMMUNE-RESPONSE; IMMUNOTHERAPY; IRRADIATION; MECHANISMS; DEATH; HEAD; COMBINATION;
D O I
10.3390/ijms232012263
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Therapeutic cancer vaccines have become firmly established as a reliable and proficient form of tumor immunotherapy. They represent a promising approach for substantial advancements in the successful treatment of malignant diseases. One attractive vaccine strategy is using, as the vaccine material, the whole tumor cells treated ex vivo by rapid tumor ablation therapies that instigate stress signaling responses culminating in immunogenic cell death (ICD). One such treatment is photodynamic therapy (PDT). The underlying mechanisms and critical elements responsible for the potency of these vaccines are discussed in this review. Radiotherapy has emerged as a suitable component for the combined therapy protocols with the vaccines. Arguments and prospects for optimizing tumor control using a radiovaccination strategy involving X-ray irradiation plus PDT vaccines are presented, together with the findings supporting its validity.
引用
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页数:10
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