Proton MR spectroscopy in multiple sclerosis

被引:0
|
作者
Arnold, DL
De Stefano, N
Narayanan, S
Matthews, PM
机构
[1] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ, Canada
[2] Univ Siena, Dept Neurol, Neurometab Unit, I-53100 Siena, Italy
[3] Univ Oxford, Dept Neurol, Ctr Funct Magnet Resonance Imaging Brain, Oxford, England
关键词
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Axonal injury in multiple sclerosis (MS) is focal and diffuse, and is directly responsible for irreversible disability. Acute inflammatory events can be associated with reversible disability that may parallel reversible axonal injury. This in part accounts for the remission following relapses early in the disease. By the time there is clinical disability, substantial axonal injury already has occurred. This provides a strong rationale for the early limitation of inflammation and its consequences.
引用
收藏
页码:789 / +
页数:12
相关论文
共 50 条
  • [31] Volume correction for edema in single-volume proton MR spectroscopy of contrast-enhancing multiple sclerosis lesions
    Helms, G
    MAGNETIC RESONANCE IN MEDICINE, 2001, 46 (02) : 256 - 263
  • [32] Benign versus secondary-progressive multiple sclerosis: The potential role of proton MR spectroscopy in defining the nature of disability
    Falini, A
    Calabrese, G
    Filippi, M
    Origgi, D
    Lipari, S
    Colombo, B
    Comi, G
    Scotti, G
    AMERICAN JOURNAL OF NEURORADIOLOGY, 1998, 19 (02) : 223 - 229
  • [33] Proton MR spectroscopy and magnetization transfer ratio in multiple sclerosis: Correlative findings of active: Versus irreversible plaque disease
    Kimura, H
    Grossman, RI
    Lenkinski, RE
    GonzalezScarano, F
    AMERICAN JOURNAL OF NEURORADIOLOGY, 1996, 17 (08) : 1539 - 1547
  • [34] Proton MR spectroscopy of lesion evolution in multiple sclerosis: Steady-state metabolism and its relationship to conventional imaging
    Kirov, Ivan I.
    Liu, Shu
    Tal, Assaf
    Wu, William E.
    Davitz, Matthew S.
    Babb, James S.
    Rusinek, Henry
    Herbert, Joseph
    Gonen, Oded
    HUMAN BRAIN MAPPING, 2017, 38 (08) : 4047 - 4063
  • [35] Relationship between brain MRI and proton MR spectroscopy indices and clinical disability in a longitudinal study of patients with multiple sclerosis
    DeStefano, N
    Fu, L
    Narayanan, S
    Matthews, PM
    Stanley, JA
    Francis, GS
    Antel, JP
    Arnold, DL
    NEUROLOGY, 1996, 46 (02) : 70006 - 70006
  • [36] Proton MR spectroscopy of the foramen of Monro region in patients with tuberous sclerosis complex
    de Carvalho-Neto, Arnolfo
    Bruck, Isac
    Antoniuk, Sergio A.
    Marchiori, Edson
    Gasparetto, Emerson L.
    ARQUIVOS DE NEURO-PSIQUIATRIA, 2008, 66 (2B) : 303 - 307
  • [37] MR imaging and localized proton spectroscopy of the precentral gyrus in amyotrophic lateral sclerosis
    Bowen, BC
    Pattany, PM
    Bradley, WG
    Murdoch, JB
    Rotta, F
    Younis, AA
    Duncan, RC
    Quencer, RM
    AMERICAN JOURNAL OF NEURORADIOLOGY, 2000, 21 (04) : 647 - 658
  • [38] ltra-High Field Proton MR Spectroscopy in Amyotrophic Lateral Sclerosis
    Cheong, Ian
    Oz, Gulin
    Eberly, Lynn
    Marjanska, Malgorzata
    Walk, David
    NEUROLOGY, 2017, 88
  • [39] MR spectroscopy indicates diffuse multiple sclerosis activity during remission
    Kirov, I. I.
    Patil, V.
    Babb, J. S.
    Rusinek, H.
    Herbert, J.
    Gonen, O.
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2009, 80 (12): : 1330 - 1336
  • [40] Can MR spectroscopy predict multiple sclerosis and its clinical symptoms?
    Quadrelli, S.
    Ribbons, K.
    Lea, R.
    Arm, J.
    Al-Iedani, O.
    Ramadan, S.
    Lechner-Scott, J.
    MULTIPLE SCLEROSIS JOURNAL, 2018, 24 : 228 - 228