Corona virus disease (COVID-19) has created pandemic in the world as declared by WHO on March 12, 2020. It is a viral disease caused by SARS-CoV 2 virus and has affected large populations in over 120 countries. There is no specific treatment available and management is empirical. Until such time that an effective vaccine is available for COVID-19 viral infection, one can repurpose known therapeutic drug molecules such as angiotensin receptor 2 blocker, a commonly used antihypertensive drug, to control COVID-19 virus from gaining entry into the host cell by blocking the angiotensin receptor. Clinical trials should also be undertaken to use statins, which are lipid-lowering drugs but have anti-inflammatory and immunomodulatory properties to prevent acute lung injury in COVID-19 infection.
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Mangalbare Hosp, Dept Emergency Med & Gen Practice, Morang, NepalShree Birendra Hosp, Nepalese Army Inst Hlth Sci, Dept Pharm, Kathmandu, Nepal
Shrestha, Dhan Bahadur
Budhathoki, Pravash
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Dr Iwamura Mem Hosp, Dept Emergency Med & Gen Practice, Bhaktapur, NepalShree Birendra Hosp, Nepalese Army Inst Hlth Sci, Dept Pharm, Kathmandu, Nepal
机构:
Univ Iowa, Coll Med, Holden Comprehens Canc Ctr, Iowa City, IA USA
Univ Iowa, Coll Med, Dept Pathol, Iowa City, IA 52242 USA
Univ Iowa, Coll Med, Canc Biol Grad Program, Iowa City, IA USA
Univ Iowa, Coll Med, Med Scientist Training Program, Iowa City, IA USAUniv Iowa, Coll Med, Holden Comprehens Canc Ctr, Iowa City, IA USA
Borcherding, Nicholas
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Jethava, Yogesh
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Vikas, Praveen
DRUG DESIGN DEVELOPMENT AND THERAPY,
2020,
14
: 5045
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5058
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Harvard Med Sch Boston, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USAHarvard Med Sch Boston, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA
Wang, Rui-Sheng
Loscalzo, Joseph
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Harvard Med Sch Boston, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA
Harvard Med Sch Boston, Brigham & Womens Hosp, Dept Med, Div Cardiovasc Med, 77 Ave Louis Pasteur,6th Floor,Room 0630M, Boston, MA 02115 USAHarvard Med Sch Boston, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA