Contrast solution properties and scan parameters influence the apparent diffusivity of computed tomography contrast agents in articular cartilage

被引:1
|
作者
Hall, Mary E. [1 ]
Wang, Adam S. [2 ,3 ]
Gold, Garry E. [2 ,4 ]
Levenston, Marc E. [1 ,2 ]
机构
[1] Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Radiol, Stanford, CA 94305 USA
[3] Stanford Univ, Dept Elect Engn, Stanford, CA 94305 USA
[4] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
基金
美国国家卫生研究院;
关键词
computed tomography; contrast agents; articular cartilage; diffusion; biomarker; osteoarthritis; KNEE ARTHROGRAPHY; CT ARTHROGRAPHY; DRUG-DELIVERY; TRANSPORT; CHARGE; OSTEOARTHRITIS; GLYCOSAMINOGLYCANS; DIAGNOSTICS; IOXAGLATE; ACCURACY;
D O I
10.1098/rsif.2022.0403
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The inability to detect early degenerative changes to the articular cartilage surface that commonly precede bulk osteoarthritic degradation is an obstacle to early disease detection for research or clinical diagnosis. Leveraging a known artefact that blurs tissue boundaries in clinical arthrograms, contrast agent (CA) diffusivity can be derived from computed tomography arthrography (CTa) scans. We combined experimental and computational approaches to study protocol variations that may alter the CTa-derived apparent diffusivity. In experimental studies on bovine cartilage explants, we examined how CA dilution and transport direction (absorption versus desorption) influence the apparent diffusivity of untreated and enzymatically digested cartilage. Using multiphysics simulations, we examined mechanisms underlying experimental observations and the effects of image resolution, scan interval and early scan termination. The apparent diffusivity during absorption decreased with increasing CA concentration by an amount similar to the increase induced by tissue digestion. Models indicated that osmotically-induced fluid efflux strongly contributed to the concentration effect. Simulated changes to spatial resolution, scan spacing and total scan time all influenced the apparent diffusivity, indicating the importance of consistent protocols. With careful control of imaging protocols and interpretations guided by transport models, CTa-derived diffusivity offers promise as a biomarker for early degenerative changes.
引用
收藏
页数:12
相关论文
共 50 条
  • [31] COMPARATIVE EFFICACY OF CONTRAST AGENTS IN COMPUTED TOMOGRAPHY SCANNING OF BRAIN
    NORMAN, D
    ENZMANN, DR
    NEWTON, TH
    JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1978, 2 (03) : 319 - 321
  • [32] Computed Tomography of Cartilage: An Exploration of Novel Cationic Bismuth Contrast Agent
    Bhattarai, Abhisek
    Lok, Jamie Guan-Tai
    Sun, Hongzhe
    Vardhanabhuti, Varut
    ANNALS OF BIOMEDICAL ENGINEERING, 2023, 51 (05) : 977 - 986
  • [33] TANTALUM OXIDE NANOPARTICLES FOR CONTRAST ENHANCED COMPUTED TOMOGRAPHY IMAGING OF CARTILAGE
    Jantti, J.
    Joenathan, A.
    Fugazzola, M.
    van Weeren, R.
    Synder, B. D.
    Grinstaff, M. W.
    Toyras, J.
    Matikka, H.
    Makela, J. T.
    OSTEOARTHRITIS AND CARTILAGE, 2022, 30 : S277 - S277
  • [34] Computed Tomography of Cartilage: An Exploration of Novel Cationic Bismuth Contrast Agent
    Abhisek Bhattarai
    Jamie Guan-Tai Lok
    Hongzhe Sun
    Varut Vardhanabhuti
    Annals of Biomedical Engineering, 2023, 51 : 977 - 986
  • [35] Potential of high-Z contrast agents in clinical contrast-enhanced computed tomography
    Nowak, Tristan
    Hupfer, Martin
    Brauweiler, Robert
    Eisa, Fabian
    Kalender, Willi A.
    MEDICAL PHYSICS, 2011, 38 (12) : 6469 - 6482
  • [36] Diffusion of MRI and CT Contrast Agents in Articular Cartilage under Static Compression
    Shafieyan, Yousef
    Khosravi, Niloufar
    Moeini, Mohammad
    Quinn, Thomas M.
    BIOPHYSICAL JOURNAL, 2014, 107 (02) : 485 - 492
  • [37] Effect of Contrast Agent Charge on Visualization of Articular Cartilage Using Computed Tomography: Exploiting Electrostatic Interactions for Improved Sensitivity
    Joshi, Neel S.
    Bansal, Prashant N.
    Stewart, Rachel C.
    Snyder, Brian D.
    Grinstaff, Mark W.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (37) : 13234 - 13235
  • [38] Depth-Dependent Glycosaminoglycan Concentration in Articular Cartilage by Quantitative Contrast-Enhanced Micro-Computed Tomography
    Mittelstaedt, Daniel
    Xia, Yang
    CARTILAGE, 2015, 6 (04) : 216 - 225
  • [39] Quantitative Dual Contrast CT Technique for Evaluation of Articular Cartilage Properties
    Bhattarai, Abhisek
    Honkanen, Juuso T. J.
    Myller, Katariina A. H.
    Prakash, Mithilesh
    Korhonen, Miitu
    Saukko, Annina E. A.
    Viren, Tuomas
    Joukainen, Antti
    Patwa, Amit N.
    Kroger, Heikki
    Grinstaff, Mark W.
    Jurvelin, Jukka S.
    Toyras, Juha
    ANNALS OF BIOMEDICAL ENGINEERING, 2018, 46 (07) : 1038 - 1046
  • [40] Quantitative Dual Contrast CT Technique for Evaluation of Articular Cartilage Properties
    Abhisek Bhattarai
    Juuso T. J. Honkanen
    Katariina A. H. Myller
    Mithilesh Prakash
    Miitu Korhonen
    Annina E. A. Saukko
    Tuomas Virén
    Antti Joukainen
    Amit N. Patwa
    Heikki Kröger
    Mark W. Grinstaff
    Jukka S. Jurvelin
    Juha Töyräs
    Annals of Biomedical Engineering, 2018, 46 : 1038 - 1046