Low Bone Mineral Density Is Not Associated with Subclinical Atherosclerosis: A Population-Based Study in Rural China

被引：13

作者：

Jiang, Yanfeng ^{[1
,2
,3
]}

Fan, Zehan ^{[1
,2
]}

Wang, Yingzhe ^{[4
]}

Suo, Chen ^{[3
,5
]}

Cui, Mei ^{[4
]}

Yuan, Ziyu ^{[1
,2
,3
]}

Tian, Weizhong ^{[6
]}

Fan, Min ^{[7
]}

Zhang, Dekun ^{[8
]}

Wang, Xiaofeng ^{[1
,2
,3
]}

Jin, Li ^{[1
,2
,3
]}

Ye, Weimin ^{[3
,9
]}

Li, Shuyuan ^{[3
,10
,11
]}

Chen, Xingdong ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Sch Life Sci, Human Phenome Inst, State Key Lab Genet Engn, Shanghai, Peoples R China

[2] Fudan Univ, Sch Life Sci, Human Phenome Inst, Collaborat Innovat Ctr Genet & Dev, Shanghai, Peoples R China

[3] Fudan Univ, Taizhou Inst Hlth Sci, Taizhou, Peoples R China

[4] Fudan Univ, Huashan Hosp, Inst Neurol, Shanghai, Peoples R China

[5] Fudan Univ, Sch Publ Hlth, Dept Epidemiol, Shanghai, Peoples R China

[6] Taizhou Peoples Hosp, Taizhou, Peoples R China

[7] Taixing Dis Control & Prevent Ctr, Taizhou, Peoples R China

[8] Taizhou Dis Control & Prevent Ctr, Taizhou, Peoples R China

[9] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[10] Shanghai Jiao Tong Univ, Sch Med, Inst Embryo Fetal Original Adult Dis, Shanghai 200030, Peoples R China

[11] Shanghai Jiao Tong Univ, Sch Med, Int Peace Matern & Child Hlth Hosp, Shanghai, Peoples R China

来源：

CARDIOLOGY | 2018年 / 141卷 / 02期

关键词：

Subclinical atherosclerosis; Bone mineral density; Carotid intima-media thickness; High brachial-ankle pulse wave velocity; Ankle-brachial index; Carotid plaques; INTIMA-MEDIA THICKNESS; PERIPHERAL ARTERIAL-DISEASE; ANKLE-BRACHIAL INDEX; PULSE-WAVE VELOCITY; POSTMENOPAUSAL WOMEN; STIFFNESS; RISK; CALCIFICATION; MEN; DIAGNOSIS;

D O I：

10.1159/000493166

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: Loss of bone mass may affect the progression of atherosclerosis. We investigated the relationship between low bone mineral density (BMD) and subclinical atherosclerosis in rural China. Methods: In total, 333 men and 421 postmenopausal women aged 55-65 years were enrolled. BMD was measured in the lumbar spine, femoral neck, and total hip using dual-energy X-ray absorptiometry. Subclinical atherosclerosis was defined as increased carotid artery intimamedia thickness (CIMT >= 0.9 mm), the presence of carotid plaques, high brachial-ankle pulse wave velocity (baPWV >= 1,400 cm/s), and low ankle-brachial index (ABI <= 1). Binary logistic regression analyses were used to estimate the association between low BMD and subclinical atherosclerosis. Results: There was no significant difference in BMD between the normal group and the subclinical atherosclerosis group. After full adjustment for the relevant covariates, a boundary significant association was found between low BMD in the femoral neck and baPWV in postmenopausal women (odds ratio = 1.77, p = 0.049). After full adjustment, neither BMD nor low BMD were significantly associated with subclinical atherosclerosis in men or postmenopausal women. Conclusions: Low BMD is not associated with subclinical atherosclerosis in Chinese individuals aged 55-65 years resident in rural China. (C) 2018 S. Karger AG, Basel

引用

页码：78 / 87

页数：10

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