Genetic polymorphisms of FADS1, FADS2, and FADS3 and fatty acid profiles in subjects received methadone maintenance therapy

被引：3
|
作者：
Yang, Hui-Ting [1 ,2 ]
Wang, Ruey-Yun [3 ]
Huang, Shih-Yi [4 ]
Huang, Chieh-Liang [5 ,6 ]
Su, Kuan-Pin [5 ,6 ,7 ]
机构：
[1] China Med Univ, Dept Nutr, Taichung, Taiwan
[2] China Med Univ, Inst Nutr, Taichung, Taiwan
[3] China Med Univ, Dept Publ Hlth, Taichung, Taiwan
[4] Taipei Med Univ, Sch Nutr & Hlth Sci, Taipei, Taiwan
[5] China Med Univ Hosp, Dept Psychiat, 2 Yuh DerYuh Der Rd, Taichung 404, Taiwan
[6] China Med Univ Hosp, Mind Body Interface Lab MBI Lab, Taichung, Taiwan
[7] China Med Univ, Grad Inst Neural & Cognit Sci, Taichung, Taiwan
来源：
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2018年 / 136卷
关键词：
Methadone; Heroin; FADS gene polymorphism; PUFA; DHA; HARDY-WEINBERG PROPORTIONS; MAJOR DEPRESSIVE DISORDER; MIND-BODY INTERFACE; ANXIETY DISORDERS; CARDIOVASCULAR-DISEASE; NUTRITIONAL MEDICINE; ALLELE FREQUENCIES; HEROIN USERS; BIASED TESTS; OMEGA-3-FATTY-ACIDS;
D O I：
10.1016/j.plefa.2017.01.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Abnormal fatty acid metabolism and the related enzymes had been observed to be associated with psychiatric disorders. We investigated FADS gene family genetic polymorphisms and variations of lipid profiles in patients with heroin dependence receiving 6-month methadone maintenance therapy (MMT). We recruited 89 MMT drug abusers and analyzed 3 tag single nucleotide polymorphisms (SNPs) from Fatty acid desaturases (FADS), FADS1, FADS2 and FADS3. The fatty acid profiles of erythrocyte membranes were analyzed based on genetic variations. Six-month MMT therapy were significantly associated with decreased C20: 5n3 and C22: 4n6 levels in the whole group of drug abusers. The decreases of C22:6n3 after MMT therapy were associated with specific genetic variations, including FADS1 C/C, FADS2 T/T and FADS3 C/C genotypes. The variations on 5n3 and n6 PUFA composition were significantly shown in different alleles of FADS in MMT drug abusers. Further studies are needed to elucidate the role of fatty acid metabolism on rehabilitation by MMT.
引用
收藏
页码：117 / 121
页数：5
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