Retrospective analysis of brain abscess in 183 patients A 10-year survey

This study aims to identify predictive factors related to clinical outcome, reoperation, and complications in patients with brain abscess. Patients with a diagnosis of brain abscess at discharge at the Second Affiliated Hospital of Zhejiang University School of Medicine between 2008 and 2018 were reviewed. Logistic regression was used to identify predictive factors associated with Glasgow Outcome Scale (GOS) at discharge, GOS at 1 year after discharge, reoperation and complications. Among 183 patients enrolled into the study, 142 patients had a good outcome at discharge (GOS >= 4) and 41 had a poor outcome (GOS <= 3). During the follow-up period, 20 additional patients had a good outcome. A total of 156 patients were treated by open craniotomy excision (n=72) and aspiration (n=84), 10 of whom underwent reoperation. Complications in surgical patients for brain abscess occurred in 54 patients. Poor outcome was related to Glasgow coma scale (P=.007) and ventricular proximity (P=.001). Surgical method was associated with reoperation (P=.04) and complications (P<.001). Seizure at admission was related to epilepsy (P<.001). Surgical method was related to postoperative intracranial hemorrhage (P=.02). Glasgow coma scale (GCS) and ventricular proximity were associated with poor outcome. Further, patients who underwent aspiration were more likely to experience reoperation, while open craniotomy excision (OCE) was related to complications. Patients presenting seizure at admission were more likely to develop epilepsy. Patients who underwent OCE tended to experience postoperative intracranial hemorrhage.