Synthesis and properties of 2'-O-methoxymethyl oligonucleotides

被引：0
|
作者：
Bizdena, E [1 ]
Rozners, E [1 ]
Stromberg, R [1 ]
机构：
[1] STOCKHOLM UNIV,ARRHENIUS LAB,DEPT ORGAN CHEM,S-10691 STOCKHOLM,SWEDEN
来源：
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1996年 / 61卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
2'-O-Methoxymethyluridine was synthesized under mild conditions using N-iodosuccinimide (NIS) activation of a 2'-methoxythiomethyl function in presence of methanol. Oligoribonucleotides containing such modified uridine residues had slightly decreased duplex stability when compared with full RNA duplexes. No substantial increase in stability towards snake venom phosphodiesterase (SVPD) was observed.
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页码：S283 / S286
页数：4
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