A Decade of Research on Daptomycin

被引：3
|
作者：
Taylor, Scott D. [1 ]
机构：
[1] Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada
来源：
SYNLETT | 2022年 / 33卷 / 17期
基金：
加拿大自然科学与工程研究理事会;
关键词：
antibiotics; daptomycin; solid-phase synthesis; mechanism; structure-activity relationships; SOLID-PHASE SYNTHESIS; GLUTAMIC ACIDS; LIPOPEPTIDE; RESISTANCE; INVITRO;
D O I：
10.1055/a-1885-4934
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Daptomycin is a calcium-dependent cyclic lipodepsipeptide antibiotic that is used in the clinic for treating serious infections caused by Gram-positive bacteria. In this account, I present a summary of the research that has been conducted in my group on daptomycin's total chemical synthesis, its structure-activity relationships, and its mechanism of action, since we began our studies a decade ago.
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页码：1695 / 1706
页数：12
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