Differential responses of primary auditory cortex in autistic spectrum disorder with auditory hypersensitivity

被引：44

作者：

Matsuzaki, Junko ^{[1
]}

Kagitani-Shimono, Kuriko ^{[1
]}

Goto, Tetsu ^{[2
,3
]}

Sanefuji, Wakako ^{[4
]}

Yamamoto, Tomoka ^{[4
]}

Sakai, Saeko ^{[1
]}

Uchida, Hiroyuki ^{[1
]}

Hirata, Masayuki ^{[2
]}

Mohri, Ikuko ^{[1
]}

Yorifuji, Shiro ^{[3
]}

Taniike, Masako ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, United Grad Sch Child Dev, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Med, Dept Neurosurg, Suita, Osaka 5650871, Japan

[3] Osaka Univ, Grad Sch Med, Div Funct Diagnost Sci, Suita, Osaka 5650871, Japan

[4] Osaka Univ, Grad Sch Med, Dept Mol Res, Ctr Childrens Mental Dev, Suita, Osaka 5650871, Japan

来源：

NEUROREPORT | 2012年 / 23卷 / 02期

关键词：

auditory-evoked field; auditory hypersensitivity; autistic spectrum disorder; magnetoencephalography; SENSORY PROFILE; EVOKED FIELDS; CHILDREN;

D O I：

10.1097/WNR.0b013e32834ebf44

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of this study was to investigate the differential responses of the primary auditory cortex to auditory stimuli in autistic spectrum disorder with or without auditory hypersensitivity. Auditory-evoked field values were obtained from 18 boys (nine with and nine without auditory hypersensitivity) with autistic spectrum disorder and 12 age-matched controls. Autistic disorder with hypersensitivity showed significantly more delayed M50/M100 peak latencies than autistic disorder without hypersensitivity or the control. M50 dipole moments in the hypersensitivity group were statistically larger than those in the other two groups. M50/M100 peak latencies were correlated with the severity of auditory hypersensitivity; furthermore, severe hypersensitivity induced more behavioral problems. This study indicates auditory hypersensitivity in autistic spectrum disorder as a characteristic response of the primary auditory cortex, possibly resulting from neurological immaturity or functional abnormalities in it. NeuroReport 23:113-118 (C) 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.

引用

页码：113 / 118

页数：6

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