Synthesis of novel thiopyrimidines: an investigation of anti-tubercular and antimicrobial activity

被引：12
|
作者：
Haveliwala, Dhaval D. [1 ]
Kamdar, Nimesh R. [1 ]
Mistry, Prashant T. [1 ]
Patel, Saurabh K. [1 ]
机构：
[1] Veer Narmad S Gujarat Univ, Dept Chem, Surat 395007, Gujarat, India
来源：
JOURNAL OF SULFUR CHEMISTRY | 2011年 / 32卷 / 05期
关键词：
thiopyrimidines; dithiopyrimidines; chromone; anti-tubercular activity; antimicrobial activity; PYRIDINE; DERIVATIVES;
D O I：
10.1080/17415993.2010.523894
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A variety of novel sulfur-containing tricyclic pyrimidine derivatives have been synthesized via the reaction of 2-amino-4-oxo-4H-chromene-3-carbonitriles 3(a-f) with different reagents and characterized by IR, H-1 NMR, C-13 NMR, mass spectrometry and elemental analysis. The anti-tubercular and antimicrobial activities of the synthesized compounds were investigated. [GRAPHICS] .
引用
收藏
页码：451 / 462
页数：12
相关论文
共 50 条
  • [1] SYNTHESIS OF SULFONES WITH ANTI-TUBERCULAR ACTIVITY
    MERCHANT, JR
    KOSHTI, NM
    GUPTA, AS
    CHEMISTRY & INDUSTRY, 1982, (23) : 955 - 955
  • [2] Synthesis, structural activity relationship and anti-tubercular activity of novel pyrazoline derivatives
    Ali, Mohamed Ashraf
    Shaharyar, Mohammad
    Siddiqui, Anees Ahamed
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (02) : 268 - 275
  • [3] Synthesis of novel 4-nitropyrrole-based semicarbazide and thiosemicarbazide hybrids with antimicrobial and anti-tubercular activity
    Rane, Rajesh A.
    Naphade, Shital S.
    Bangalore, Pavan Kumar
    Palkar, Mahesh B.
    Shaikh, Mahamadhanif S.
    Karpoormath, Rajshekhar
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (14) : 3079 - 3083
  • [4] SYNTHESIS OF COUMARYLTHIOHYDATOINS HAVING ANTI-TUBERCULAR ACTIVITY
    MERCHANT, JR
    GUPTA, AS
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1978, 16 (01): : 71 - 72
  • [5] SYNTHESIS OF SOME QUINONES OF POTENTIAL ANTI-TUBERCULAR ACTIVITY
    ROUSHDI, IM
    HABIB, NS
    PHARMAZIE, 1977, 32 (10): : 562 - 563
  • [6] Design, Synthesis and Anti-Tubercular Activity of Isoniazid Derivatives
    Imran, Mohd
    Bawadekji, Abdulhakim
    Al Ali, Mouhanad
    RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES, 2018, 9 (05): : 2413 - 2419
  • [7] Fluoroquinolones: a review on anti-tubercular activity
    Joshi, Sapna
    Yadav, Divya
    Yadav, Rakesh
    MONATSHEFTE FUR CHEMIE, 2021, 152 (08): : 881 - 894
  • [8] Triazole derivatives and their anti-tubercular activity
    Zhang, Shu
    Xu, Zhi
    Gao, Chuan
    Ren, Qing-Cheng
    Chang, Le
    Lv, Zao-Sheng
    Feng, Lian-Shun
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 138 : 501 - 513
  • [9] SYNTHESIS AND ANTI-TUBERCULAR ACTIVITY OF NOVEL PYRAZOL-5(H)-ONE DERIVATIVES
    Raval, Jignesh P.
    Patel, Purvesh R.
    Gandhi, Ankur N.
    Shah, Arpita B.
    Patel, Pradip S.
    MEDICINAL CHEMISTRY RESEARCH, 2010, 19 : S73 - S73
  • [10] Isoniazid derivatives and their anti-tubercular activity
    Hu, Yuan-Qiang
    Zhang, Shu
    Zhao, Feng
    Gao, Chuan
    Feng, Lian-Shun
    Lv, Zao-Sheng
    Xu, Zhi
    Wu, Xiang
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 133 : 255 - 267
12345