Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging

被引：29
|
作者：
Rossi, Martina [1 ]
Gorospe, Myriam [1 ]
机构：
[1] NIA, Lab Genet & Genom, Intramural Res Program, NIH, Baltimore, MD 21224 USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2020年 / 26卷 / 04期
基金：
美国国家卫生研究院;
关键词：
REPEAT-CONTAINING RNA; CELLULAR SENESCENCE; GENE-EXPRESSION; BREAST-CANCER; CELLS; TERRA; DNA; MICRORNAS; PROTEIN; TRANSCRIPTION;
D O I：
10.1016/j.molmed.2020.01.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aging is a universal and time-dependent biological decline associated with progressive deterioration of cells, tissues, and organs. Age-related decay can eventually lead to pathology such as cardiovascular and neurodegenerative diseases, cancer, and diabetes. A prominent molecular process underlying aging is the progressive shortening of telomeres, the structures that protect the ends of chromosomes, eventually triggering cellular senescence. Noncoding (nc)RNAs are emerging as major regulators of telomere length homeostasis. In this review, we describe the impact of ncRNAs on telomere function and discuss their implications in senescence and age-related diseases. We discuss emerging therapeutic strategies targeting telomere-regulatory ncRNAs in aging pathology. © 2020
引用
收藏
页码：422 / 433
页数：12
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