DIRECT BINDING OF COMPOUNDS TO HUMAN CFTR NBD1: ALLOSTERY AND THE IMPORTANCE OF DOMAIN-DOMAIN INTERACTIONS

被引：0
|
作者：
Hudson, Rhea [1 ]
Dawson, Jennifer E. [1 ]
Chong, P. Andrew [1 ]
Vernon, Robert [1 ]
Yang, Zengrong [3 ]
Millen, Linda [4 ]
Thomas, Philip J. [4 ]
Brouillette, Christie [3 ]
Forman-Kay, Julie [1 ,2 ]
机构：
[1] Hosp Sick Children, Toronto, ON, Canada
[2] Univ Toronto, Toronto, ON, Canada
[3] Univ Alabama Birmingham, Birmingham, AL USA
[4] Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA
来源：
PEDIATRIC PULMONOLOGY | 2016年 / 51卷
关键词：
TRANSMEMBRANE CONDUCTANCE REGULATOR;
D O I：
暂无
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
S08.1
引用
收藏
页码：141 / 142
页数：2
相关论文
共 50 条
  • [21] Functional Stabilization of Purified Human CFTR by NBD1 Mutations and by Phosphatidylserine
    Urbatsch, Ina
    Yang, Zhengrong
    Hildebrandt, Ellen
    Jiang, Fan
    Zhou, Qingxian
    An, Jiangli
    Xavier, Bala M.
    Khazanov, Netaly
    Senderowitz, Hanoch
    Kappes, John C.
    Brouillette, Christie G.
    BIOPHYSICAL JOURNAL, 2018, 114 (03) : 245A - 245A
  • [22] INTERACTION OF SMALL-MOLECULE CFTR MODULATORS WITH HUMAN NBD1
    Hudson, R.
    Chong, P.
    Kolodziej, A.
    Thomas, P. J.
    Forman-Kay, J. D.
    PEDIATRIC PULMONOLOGY, 2009, : 216 - 216
  • [23] Nucleotide binding domain 1 (NBD1) of the human retinal ABC transporter gene (ABCR): Cloning, expression and characterization.
    Biswas, EE
    Biswas, SB
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2001, 42 (04) : S653 - S653
  • [24] Nanomechanics combined with HDX reveals allosteric drug binding sites of CFTR NBD1
    Padanyi, Rita
    Farkas, Bianka
    Tordai, Hedvig
    Kiss, Balint
    Grubmueller, Helmut
    Soya, Naoto
    Lukacs, Gergely L.
    Kellermayer, Miklos
    Hegedus, Tamas
    COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2022, 20 : 2587 - 2599
  • [25] Correction of Both NBD1 Energetics and Domain Interface Is Required to Restore ΔF508 CFTR Folding and Function
    Rabeh, Wael M.
    Bossard, Florian
    Xu, Haijin
    Okiyoneda, Tsukasa
    Bagdany, Miklos
    Mulvihill, Cory M.
    Du, Kai
    di Bernardo, Salvatore
    Liu, Yuhong
    Konermann, Lars
    Roldan, Ariel
    Lukacs, Gergely L.
    CELL, 2012, 148 (1-2) : 150 - 163
  • [26] DELETION OF F508 ALTERS THE DYNAMICS OF HUMAN CFTR NBD1
    Chong, P.
    Hudson, R. P.
    Forman-Kay, J. D.
    PEDIATRIC PULMONOLOGY, 2009, : 213 - 213
  • [27] Differences in interactions of wt and ΔF508 NBD1 with other regions of CFTR
    Kanelis, V.
    Hudson, R. P.
    Baker, J. M.
    Thibodeau, P. H. .
    Thomas, P. J.
    Forman-Kay, J. D.
    PEDIATRIC PULMONOLOGY, 2007, : 202 - 202
  • [28] Nanomechanics combined with HDX reveals allosteric drug binding sites of CFTR NBD1
    Padanyi, Rita
    Farkas, Bianka
    Tordai, Hedvig
    Kiss, Balint
    Grubmueller, Helmut
    Soya, Naoto
    Lukacs, Gergely L.
    Kellermayer, Miklos
    Hegedus, Tamas
    COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2022, 20 : 2587 - 2599
  • [29] DOMAIN-DOMAIN INTERACTIONS IN THE FULL-LENGTH HUMAN CFTR PROTEIN REVEALED BY SINGLE PARTICLE ELECTRON MICROSCOPY AND ELECTRON CRYSTALLOGRAPHY
    Ford, Robert C.
    Rosenberg, Mark F.
    O'Ryan, Liam
    Hughes, Guy
    Zhao, Zhefeng
    Aleksandrov, Luba
    Riordan, John R.
    PEDIATRIC PULMONOLOGY, 2011, : 121 - 123
  • [30] Functional evaluation of domain-domain interactions and human protein interaction networks
    Schlicker, Andreas
    Huthmacher, Carola
    Ramirez, Fidel
    Lengauer, Thomas
    Albrecht, Mario
    BIOINFORMATICS, 2007, 23 (07) : 859 - 865
12345